Monoclonal antibodies against S2 subunit of spike protein exhibit broad reactivity toward SARS-CoV-2 variants

Monoclonal antibodies against S2 subunit of spike protein exhibit broad reactivity toward SARS-CoV-2 variants

Abstract Background The variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) harbor diverse spike (S) protein sequences, which can greatly influence the efficacies of therapeutics. Therefore, it would be of great value to develop neutralizing monoclonal antibodies (mAbs) that can...

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Bibliographic Details
Main Authors: Shih-Han Ko, Wan-Yu Chen, Shih-Chieh Su, Hsiu-Ting Lin, Feng-Yi Ke, Kang-Hao Liang, Fu-Fei Hsu, Monika Kumari, Chi-Yu Fu, Han-Chung Wu
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Biomedical Science
Subjects:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Spike (S) protein
Monoclonal antibody
Phage display
B cell epitope
Online Access:https://doi.org/10.1186/s12929-022-00891-2

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