Preparation and Characterization of Amorphous Solid Dispersions for the Solubilization of Fenretinide

Preparation and Characterization of Amorphous Solid Dispersions for the Solubilization of Fenretinide

Fenretinide (4-HPR), a retinoid derivative, has shown high antitumor activity, a low toxicological profile, and no induction of resistance. Despite these favorable features, the variability in oral absorption due to its low solubility combined with the high hepatic first pass effect strongly reduce...

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Bibliographic Details
Main Authors: Guendalina Zuccari, Eleonora Russo, Carla Villa, Alessia Zorzoli, Danilo Marimpietri, Leonardo Marchitto, Silvana Alfei
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Pharmaceuticals
Subjects:
Fenretinide
neuroblastoma
drug delivery
nanoparticles
co-precipitation
lipophilic drugs
Online Access:https://www.mdpi.com/1424-8247/16/3/388

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