Comparison of clinical features, management and outcomes of osteosarcoma located in proximal fibula and proximal tibia: a propensity score matching analysis
Abstract Background The aim of this study was to compare proximal fibular and proximal tibial sites regarding osteosarcoma in the proximal crus. Furthermore, we proposed a hypothesis explaining the differences. Methods From Jaunary 2000 to February 2015, 28 patients with non-metastatic proximal fibu...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-11-01
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| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12885-018-5062-6 |
| _version_ | 1818539678294343680 |
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| author | Hao Yao Bo Wang Lili Wen Qinglin Jin Hongbo Li Gang Huang Junqiang Yin Changye Zou Xianbiao Xie Jingnan Shen |
| author_facet | Hao Yao Bo Wang Lili Wen Qinglin Jin Hongbo Li Gang Huang Junqiang Yin Changye Zou Xianbiao Xie Jingnan Shen |
| author_sort | Hao Yao |
| collection | DOAJ |
| description | Abstract Background The aim of this study was to compare proximal fibular and proximal tibial sites regarding osteosarcoma in the proximal crus. Furthermore, we proposed a hypothesis explaining the differences. Methods From Jaunary 2000 to February 2015, 28 patients with non-metastatic proximal fibular osteosarcoma and 214 patients with non-metastatic proximal tibial osteosarcoma underwent surgery were identified in our center. All clinical data were analyzed retrospectively. Propensity score matching of patients in a 1:2 ratio was conducted based on age, gender and Enneking stage. To analyze possible factors resulting in amputation, we investigated extraosseous tumor volumes (ETVS), the nearest of the blood vessel to reactive zone (NBR) and the nearest of the blood vessel to tumor (NBT). Results Amputation rates were higher in the proximal fibula cohort (35.7%) than in the proximal tibia cohort (14.3%; p = 0.046). Comparing possible clinical characteristics related with amputation between two cohorts, the proximal fibula cohort had larger ETVS (p = 0.000). Moreover, the proximal fibula cohort had a smaller NBT for anterior tibial vessels (p = 0.025), a smaller NBR for posterior tibial vessels (p = 0.013) and a smaller NBT for posterior tibial vessels (p = 0.007) than the proximal tibia cohort. Univarite and multivariable analyses showed that NBT for posterior tibial vessels was the only independent factor associated with amputation. The 3-year event-free survival (EFS) and overall survival (OS) rates for the proximal fibula cohort vs. the proximal tibia cohort were 52.6% vs. 78.0% (p = 0.045) and 63.7% vs. 81.2% (p = 0.177), respectively. The MSTS scores for the functional evaluation of limb-salvaging surgery were similar in both groups (p = 0.212). Conclusions Amputation rates among patients were higher when osteosarcoma was located in proximal fibula than in proximal tibia. A smaller NBT for posterior tibial vessels was associated with higher amputation rates. Prognosis of the proximal fibula cohort was poorer than that of the proximal tibia cohort of osteosarcoma patients. |
| first_indexed | 2024-12-11T21:45:16Z |
| format | Article |
| id | doaj.art-738989784c404bdcb099df65b7c8b8b8 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-11T21:45:16Z |
| publishDate | 2018-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-738989784c404bdcb099df65b7c8b8b82022-12-22T00:49:40ZengBMCBMC Cancer1471-24072018-11-0118111010.1186/s12885-018-5062-6Comparison of clinical features, management and outcomes of osteosarcoma located in proximal fibula and proximal tibia: a propensity score matching analysisHao Yao0Bo Wang1Lili Wen2Qinglin Jin3Hongbo Li4Gang Huang5Junqiang Yin6Changye Zou7Xianbiao Xie8Jingnan Shen9Department of Musculoskeletal Oncology Center, The First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Musculoskeletal Oncology Center, The First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Anesthesiology, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer CenterDepartment of Musculoskeletal Oncology Center, The First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Musculoskeletal Oncology Center, The First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Musculoskeletal Oncology Center, The First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Musculoskeletal Oncology Center, The First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Musculoskeletal Oncology Center, The First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Musculoskeletal Oncology Center, The First Affiliated Hospital of Sun Yat-sen UniversityDepartment of Musculoskeletal Oncology Center, The First Affiliated Hospital of Sun Yat-sen UniversityAbstract Background The aim of this study was to compare proximal fibular and proximal tibial sites regarding osteosarcoma in the proximal crus. Furthermore, we proposed a hypothesis explaining the differences. Methods From Jaunary 2000 to February 2015, 28 patients with non-metastatic proximal fibular osteosarcoma and 214 patients with non-metastatic proximal tibial osteosarcoma underwent surgery were identified in our center. All clinical data were analyzed retrospectively. Propensity score matching of patients in a 1:2 ratio was conducted based on age, gender and Enneking stage. To analyze possible factors resulting in amputation, we investigated extraosseous tumor volumes (ETVS), the nearest of the blood vessel to reactive zone (NBR) and the nearest of the blood vessel to tumor (NBT). Results Amputation rates were higher in the proximal fibula cohort (35.7%) than in the proximal tibia cohort (14.3%; p = 0.046). Comparing possible clinical characteristics related with amputation between two cohorts, the proximal fibula cohort had larger ETVS (p = 0.000). Moreover, the proximal fibula cohort had a smaller NBT for anterior tibial vessels (p = 0.025), a smaller NBR for posterior tibial vessels (p = 0.013) and a smaller NBT for posterior tibial vessels (p = 0.007) than the proximal tibia cohort. Univarite and multivariable analyses showed that NBT for posterior tibial vessels was the only independent factor associated with amputation. The 3-year event-free survival (EFS) and overall survival (OS) rates for the proximal fibula cohort vs. the proximal tibia cohort were 52.6% vs. 78.0% (p = 0.045) and 63.7% vs. 81.2% (p = 0.177), respectively. The MSTS scores for the functional evaluation of limb-salvaging surgery were similar in both groups (p = 0.212). Conclusions Amputation rates among patients were higher when osteosarcoma was located in proximal fibula than in proximal tibia. A smaller NBT for posterior tibial vessels was associated with higher amputation rates. Prognosis of the proximal fibula cohort was poorer than that of the proximal tibia cohort of osteosarcoma patients.http://link.springer.com/article/10.1186/s12885-018-5062-6OsteosarcomaProximal fibulaProximal tibiaAmputation ratesClinical outcomes |
| spellingShingle | Hao Yao Bo Wang Lili Wen Qinglin Jin Hongbo Li Gang Huang Junqiang Yin Changye Zou Xianbiao Xie Jingnan Shen Comparison of clinical features, management and outcomes of osteosarcoma located in proximal fibula and proximal tibia: a propensity score matching analysis BMC Cancer Osteosarcoma Proximal fibula Proximal tibia Amputation rates Clinical outcomes |
| title | Comparison of clinical features, management and outcomes of osteosarcoma located in proximal fibula and proximal tibia: a propensity score matching analysis |
| title_full | Comparison of clinical features, management and outcomes of osteosarcoma located in proximal fibula and proximal tibia: a propensity score matching analysis |
| title_fullStr | Comparison of clinical features, management and outcomes of osteosarcoma located in proximal fibula and proximal tibia: a propensity score matching analysis |
| title_full_unstemmed | Comparison of clinical features, management and outcomes of osteosarcoma located in proximal fibula and proximal tibia: a propensity score matching analysis |
| title_short | Comparison of clinical features, management and outcomes of osteosarcoma located in proximal fibula and proximal tibia: a propensity score matching analysis |
| title_sort | comparison of clinical features management and outcomes of osteosarcoma located in proximal fibula and proximal tibia a propensity score matching analysis |
| topic | Osteosarcoma Proximal fibula Proximal tibia Amputation rates Clinical outcomes |
| url | http://link.springer.com/article/10.1186/s12885-018-5062-6 |
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