Protective effects of sterofundin on myocardial injury in septic rats
Objective To investigate the protective effects of sterofundin on myocardial injury in septic rats. Methods A total of 280 SPF SD rats (half male and female, 12~14 weeks old, 200~220 g) were randomly divided into 4 groups: sham operation (Sham) group, sepsis (Sep) group, conventional treatment (Ct)...
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Editorial Office of Journal of Army Medical University
2022-10-01
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| Series: | 陆军军医大学学报 |
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| Online Access: | http://aammt.tmmu.edu.cn/Upload/rhtml/202205039.htm |
| _version_ | 1797989554792169472 |
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| author | TAN Lei TAN Lei SHE Han SHE Han GUO Ningke |
| author_facet | TAN Lei TAN Lei SHE Han SHE Han GUO Ningke |
| author_sort | TAN Lei |
| collection | DOAJ |
| description | Objective To investigate the protective effects of sterofundin on myocardial injury in septic rats. Methods A total of 280 SPF SD rats (half male and female, 12~14 weeks old, 200~220 g) were randomly divided into 4 groups: sham operation (Sham) group, sepsis (Sep) group, conventional treatment (Ct) group (with Ringer's lactate solution+dopamine+cefuroxime sodium), and malate ringer's solution (Mr) group (with sterofundin+dopamine+cefuroxime sodium). The rat model of sepsis was inflicted by cecal ligation and puncture (CLP). Subsequently, the effects of sterofundin treatment on the myocardial injury, cardiac output (CO), oxygen supply and consumption, liver and kidney perfusion, liver and kidney functions, survival time and survival rate of septic rats were observed. Results The cardiac output (CO), cardiac index (CI) and stroke index (SI) were significantly decreased in the Sep group, while the injuries were improved to some extent in the Ct group (P < 0.05). As compared with the Sep group, the improvement was more obvious in the Mr group, with CO, CI and SI values increased by 48.9%, 52.9% and 21.7% respectively, and the values were also greatly higher than those in the Ct group (P < 0.05). The mean arterial blood pressure was remarkably declined to about 70 mmHg in the Sep group, slightly improved to around 90 mmHg in the Ct group, and notably elevated in the Mr group by 43.2% when compared with the Sep group (P < 0.05). In addition, the liver and kidney functions were significantly ameliorated in the Mr group, along with decreased troponin T and lactate dehydrogenase, enhanced oxygen supply and consumption, alleviated myocardial interstitial edema and less myocardial fiber breakage, which greatly improved the survival rate of animals (P < 0.05). Conclusion Sterofundin obviously improves the heart function and thus plays a protective role in organ functions in septic rats.
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| first_indexed | 2024-04-11T08:21:24Z |
| format | Article |
| id | doaj.art-738bc8a52eb34baf90845872b64f1040 |
| institution | Directory Open Access Journal |
| issn | 2097-0927 |
| language | zho |
| last_indexed | 2024-04-11T08:21:24Z |
| publishDate | 2022-10-01 |
| publisher | Editorial Office of Journal of Army Medical University |
| record_format | Article |
| series | 陆军军医大学学报 |
| spelling | doaj.art-738bc8a52eb34baf90845872b64f10402022-12-22T04:34:56ZzhoEditorial Office of Journal of Army Medical University陆军军医大学学报2097-09272022-10-0144202054206010.16016/j.2097-0927.202205039Protective effects of sterofundin on myocardial injury in septic rats TAN Lei0TAN Lei1SHE Han2SHE Han3 GUO Ningke4Department of Anesthesiology, Army Medical Center of PLA, Chongqing, 400042, China;State Key Laboratory of Trauma, Burns and Combined Injuries, Department of War Wound Shock and Transfusion, Institute of Surgery Research, Army Medical Center of PLA, Chongqing, 400042, China Department of Anesthesiology, Army Medical Center of PLA, Chongqing, 400042, China;State Key Laboratory of Trauma, Burns and Combined Injuries, Department of War Wound Shock and Transfusion, Institute of Surgery Research, Army Medical Center of PLA, Chongqing, 400042, China State Key Laboratory of Trauma, Burns and Combined Injuries, Department of War Wound Shock and Transfusion, Institute of Surgery Research, Army Medical Center of PLA, Chongqing, 400042, China Objective To investigate the protective effects of sterofundin on myocardial injury in septic rats. Methods A total of 280 SPF SD rats (half male and female, 12~14 weeks old, 200~220 g) were randomly divided into 4 groups: sham operation (Sham) group, sepsis (Sep) group, conventional treatment (Ct) group (with Ringer's lactate solution+dopamine+cefuroxime sodium), and malate ringer's solution (Mr) group (with sterofundin+dopamine+cefuroxime sodium). The rat model of sepsis was inflicted by cecal ligation and puncture (CLP). Subsequently, the effects of sterofundin treatment on the myocardial injury, cardiac output (CO), oxygen supply and consumption, liver and kidney perfusion, liver and kidney functions, survival time and survival rate of septic rats were observed. Results The cardiac output (CO), cardiac index (CI) and stroke index (SI) were significantly decreased in the Sep group, while the injuries were improved to some extent in the Ct group (P < 0.05). As compared with the Sep group, the improvement was more obvious in the Mr group, with CO, CI and SI values increased by 48.9%, 52.9% and 21.7% respectively, and the values were also greatly higher than those in the Ct group (P < 0.05). The mean arterial blood pressure was remarkably declined to about 70 mmHg in the Sep group, slightly improved to around 90 mmHg in the Ct group, and notably elevated in the Mr group by 43.2% when compared with the Sep group (P < 0.05). In addition, the liver and kidney functions were significantly ameliorated in the Mr group, along with decreased troponin T and lactate dehydrogenase, enhanced oxygen supply and consumption, alleviated myocardial interstitial edema and less myocardial fiber breakage, which greatly improved the survival rate of animals (P < 0.05). Conclusion Sterofundin obviously improves the heart function and thus plays a protective role in organ functions in septic rats. http://aammt.tmmu.edu.cn/Upload/rhtml/202205039.htmsepsissterofundinmyocardial injurysodium malate |
| spellingShingle | TAN Lei TAN Lei SHE Han SHE Han GUO Ningke Protective effects of sterofundin on myocardial injury in septic rats 陆军军医大学学报 sepsis sterofundin myocardial injury sodium malate |
| title | Protective effects of sterofundin on myocardial injury in septic rats |
| title_full | Protective effects of sterofundin on myocardial injury in septic rats |
| title_fullStr | Protective effects of sterofundin on myocardial injury in septic rats |
| title_full_unstemmed | Protective effects of sterofundin on myocardial injury in septic rats |
| title_short | Protective effects of sterofundin on myocardial injury in septic rats |
| title_sort | protective effects of sterofundin on myocardial injury in septic rats |
| topic | sepsis sterofundin myocardial injury sodium malate |
| url | http://aammt.tmmu.edu.cn/Upload/rhtml/202205039.htm |
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