Generation of feeder-independent transgene-free iPSC lines from a young-onset Parkinson’s disease (YOPD) patient with a homozygous PLA2G6: c.2222G>A (p. Arg741Gln) mutation (NCBSi003-A) and unaffected heterozygous parent (NCBSi004-A)
Phospholipase A2 group 6 (PLA2G6, iPLA2β or PARK14) gene encodes a calcium-independent group 6 phospholipase A2 enzyme and is associated with young-onset autosomal recessive Parkinson’s disease (PD). We generated human induced pluripotent stem cell (iPSC) lines from a patient with young-onset PD car...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506123000193 |
| _version_ | 1797897303603806208 |
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| author | Renjitha Gopurappilly Thasneem Musthafa Salil Sukumaran Biju Viswanath Gaiti Hasan |
| author_facet | Renjitha Gopurappilly Thasneem Musthafa Salil Sukumaran Biju Viswanath Gaiti Hasan |
| author_sort | Renjitha Gopurappilly |
| collection | DOAJ |
| description | Phospholipase A2 group 6 (PLA2G6, iPLA2β or PARK14) gene encodes a calcium-independent group 6 phospholipase A2 enzyme and is associated with young-onset autosomal recessive Parkinson’s disease (PD). We generated human induced pluripotent stem cell (iPSC) lines from a patient with young-onset PD carrying a homozygous PLA2G6: c.2222G>A (p. Arg741Gln) mutation (NCBSi003-A) and unaffected heterozygous parent (NCBSi004-A). These iPSC lines will be used for investigating the key molecular signatures of young-onset PD (YOPD), and to understand the predictive phenotypes of the disease. |
| first_indexed | 2024-04-10T07:55:25Z |
| format | Article |
| id | doaj.art-738be464049541d5bf18c550277f0f85 |
| institution | Directory Open Access Journal |
| issn | 1873-5061 |
| language | English |
| last_indexed | 2024-04-10T07:55:25Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj.art-738be464049541d5bf18c550277f0f852023-02-23T04:30:54ZengElsevierStem Cell Research1873-50612023-03-0167103033Generation of feeder-independent transgene-free iPSC lines from a young-onset Parkinson’s disease (YOPD) patient with a homozygous PLA2G6: c.2222G>A (p. Arg741Gln) mutation (NCBSi003-A) and unaffected heterozygous parent (NCBSi004-A)Renjitha Gopurappilly0Thasneem Musthafa1Salil Sukumaran2Biju Viswanath3Gaiti Hasan4National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bengaluru 560065, India; Corresponding author.National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bengaluru 560065, IndiaDepartment of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru 560029, IndiaDepartment of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru 560029, IndiaNational Centre for Biological Sciences, Tata Institute of Fundamental Research, Bengaluru 560065, IndiaPhospholipase A2 group 6 (PLA2G6, iPLA2β or PARK14) gene encodes a calcium-independent group 6 phospholipase A2 enzyme and is associated with young-onset autosomal recessive Parkinson’s disease (PD). We generated human induced pluripotent stem cell (iPSC) lines from a patient with young-onset PD carrying a homozygous PLA2G6: c.2222G>A (p. Arg741Gln) mutation (NCBSi003-A) and unaffected heterozygous parent (NCBSi004-A). These iPSC lines will be used for investigating the key molecular signatures of young-onset PD (YOPD), and to understand the predictive phenotypes of the disease.http://www.sciencedirect.com/science/article/pii/S1873506123000193 |
| spellingShingle | Renjitha Gopurappilly Thasneem Musthafa Salil Sukumaran Biju Viswanath Gaiti Hasan Generation of feeder-independent transgene-free iPSC lines from a young-onset Parkinson’s disease (YOPD) patient with a homozygous PLA2G6: c.2222G>A (p. Arg741Gln) mutation (NCBSi003-A) and unaffected heterozygous parent (NCBSi004-A) Stem Cell Research |
| title | Generation of feeder-independent transgene-free iPSC lines from a young-onset Parkinson’s disease (YOPD) patient with a homozygous PLA2G6: c.2222G>A (p. Arg741Gln) mutation (NCBSi003-A) and unaffected heterozygous parent (NCBSi004-A) |
| title_full | Generation of feeder-independent transgene-free iPSC lines from a young-onset Parkinson’s disease (YOPD) patient with a homozygous PLA2G6: c.2222G>A (p. Arg741Gln) mutation (NCBSi003-A) and unaffected heterozygous parent (NCBSi004-A) |
| title_fullStr | Generation of feeder-independent transgene-free iPSC lines from a young-onset Parkinson’s disease (YOPD) patient with a homozygous PLA2G6: c.2222G>A (p. Arg741Gln) mutation (NCBSi003-A) and unaffected heterozygous parent (NCBSi004-A) |
| title_full_unstemmed | Generation of feeder-independent transgene-free iPSC lines from a young-onset Parkinson’s disease (YOPD) patient with a homozygous PLA2G6: c.2222G>A (p. Arg741Gln) mutation (NCBSi003-A) and unaffected heterozygous parent (NCBSi004-A) |
| title_short | Generation of feeder-independent transgene-free iPSC lines from a young-onset Parkinson’s disease (YOPD) patient with a homozygous PLA2G6: c.2222G>A (p. Arg741Gln) mutation (NCBSi003-A) and unaffected heterozygous parent (NCBSi004-A) |
| title_sort | generation of feeder independent transgene free ipsc lines from a young onset parkinson s disease yopd patient with a homozygous pla2g6 c 2222g a p arg741gln mutation ncbsi003 a and unaffected heterozygous parent ncbsi004 a |
| url | http://www.sciencedirect.com/science/article/pii/S1873506123000193 |
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