Enantiospecific electrochemical rearrangement for the synthesis of hindered triazolopyridinone derivatives
Chiral and hindered triazolopyridinone derivatives are an underexplored area of chemical space mainly due to their challenging synthesis via classical methods. Here, the authors report an electrochemical rearrangement for the synthesis of triazolopyridinones using diverse, available alkyl carboxylic...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-17389-w |
| _version_ | 1818997181067034624 |
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| author | Zenghui Ye Yanqi Wu Na Chen Hong Zhang Kai Zhu Mingruo Ding Min Liu Yong Li Fengzhi Zhang |
| author_facet | Zenghui Ye Yanqi Wu Na Chen Hong Zhang Kai Zhu Mingruo Ding Min Liu Yong Li Fengzhi Zhang |
| author_sort | Zenghui Ye |
| collection | DOAJ |
| description | Chiral and hindered triazolopyridinone derivatives are an underexplored area of chemical space mainly due to their challenging synthesis via classical methods. Here, the authors report an electrochemical rearrangement for the synthesis of triazolopyridinones using diverse, available alkyl carboxylic acids as starting materials. |
| first_indexed | 2024-12-20T21:41:33Z |
| format | Article |
| id | doaj.art-738cfb6b38a84e0f990f74d1bfe7f678 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T21:41:33Z |
| publishDate | 2020-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-738cfb6b38a84e0f990f74d1bfe7f6782022-12-21T19:25:48ZengNature PortfolioNature Communications2041-17232020-07-011111810.1038/s41467-020-17389-wEnantiospecific electrochemical rearrangement for the synthesis of hindered triazolopyridinone derivativesZenghui Ye0Yanqi Wu1Na Chen2Hong Zhang3Kai Zhu4Mingruo Ding5Min Liu6Yong Li7Fengzhi Zhang8College of Pharmaceutical Science, Zhejiang University of TechnologyZhejiang University of TechnologyCollege of Pharmaceutical Science, Zhejiang University of TechnologyCollege of Pharmaceutical Science, Zhejiang University of TechnologyCollege of Pharmaceutical Science, Zhejiang University of TechnologyCollege of Pharmaceutical Science, Zhejiang University of TechnologyCollege of Pharmaceutical Science, Zhejiang University of TechnologyCollege of Pharmaceutical Science, Zhejiang University of TechnologyCollege of Pharmaceutical Science, Zhejiang University of TechnologyChiral and hindered triazolopyridinone derivatives are an underexplored area of chemical space mainly due to their challenging synthesis via classical methods. Here, the authors report an electrochemical rearrangement for the synthesis of triazolopyridinones using diverse, available alkyl carboxylic acids as starting materials.https://doi.org/10.1038/s41467-020-17389-w |
| spellingShingle | Zenghui Ye Yanqi Wu Na Chen Hong Zhang Kai Zhu Mingruo Ding Min Liu Yong Li Fengzhi Zhang Enantiospecific electrochemical rearrangement for the synthesis of hindered triazolopyridinone derivatives Nature Communications |
| title | Enantiospecific electrochemical rearrangement for the synthesis of hindered triazolopyridinone derivatives |
| title_full | Enantiospecific electrochemical rearrangement for the synthesis of hindered triazolopyridinone derivatives |
| title_fullStr | Enantiospecific electrochemical rearrangement for the synthesis of hindered triazolopyridinone derivatives |
| title_full_unstemmed | Enantiospecific electrochemical rearrangement for the synthesis of hindered triazolopyridinone derivatives |
| title_short | Enantiospecific electrochemical rearrangement for the synthesis of hindered triazolopyridinone derivatives |
| title_sort | enantiospecific electrochemical rearrangement for the synthesis of hindered triazolopyridinone derivatives |
| url | https://doi.org/10.1038/s41467-020-17389-w |
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