LINC01094 promotes pancreatic cancer progression by sponging miR-577 to regulate LIN28B expression and the PI3K/AKT pathway
The leading cause of death in pancreatic cancer (PC) patients is the progression of cancer metastasis. Recently, long non-coding RNAs (lncRNAs) have been shown to play an important role in regulating cancer cell proliferation and metastasis; however, its molecular basis in PC remains to be explored....
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-12-01
|
| Series: | Molecular Therapy: Nucleic Acids |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2162253121002183 |
| _version_ | 1818574731681464320 |
|---|---|
| author | Chen Luo Kang Lin Cegui Hu Xiaojian Zhu Jinfeng Zhu Zhengming Zhu |
| author_facet | Chen Luo Kang Lin Cegui Hu Xiaojian Zhu Jinfeng Zhu Zhengming Zhu |
| author_sort | Chen Luo |
| collection | DOAJ |
| description | The leading cause of death in pancreatic cancer (PC) patients is the progression of cancer metastasis. Recently, long non-coding RNAs (lncRNAs) have been shown to play an important role in regulating cancer cell proliferation and metastasis; however, its molecular basis in PC remains to be explored. In this study, we observed that LINC01094 was markedly overexpressed in PC tissues and was associated with poor patient prognosis. Downregulation of LINC01094 decreased the proliferation and metastasis of PC cells and inhibited tumorigenesis and metastasis in mouse xenografts. Mechanically, LINC01094 acted as an endogenous miR-577 sponge to increase the expression of its target gene, the RNA-binding protein lin-28 homolog B (LIN28B), by decoying the miR-577, thereby activating the PI3K/AKT pathway. Our findings suggest that LINC01094 plays critical roles in proliferation and metastasis of PC, implying that LINC01094 can be regarded as a new biomarker or therapeutic target for the treatment of PC. |
| first_indexed | 2024-12-15T00:30:26Z |
| format | Article |
| id | doaj.art-738d96f10e38436d90b6a14f421b72d9 |
| institution | Directory Open Access Journal |
| issn | 2162-2531 |
| language | English |
| last_indexed | 2024-12-15T00:30:26Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Therapy: Nucleic Acids |
| spelling | doaj.art-738d96f10e38436d90b6a14f421b72d92022-12-21T22:42:01ZengElsevierMolecular Therapy: Nucleic Acids2162-25312021-12-0126523535LINC01094 promotes pancreatic cancer progression by sponging miR-577 to regulate LIN28B expression and the PI3K/AKT pathwayChen Luo0Kang Lin1Cegui Hu2Xiaojian Zhu3Jinfeng Zhu4Zhengming Zhu5Department of General Surgery, Second Affiliated Hospital of Nanchang University, Nanchang, China; Jiangxi Province Medical College of Nanchang University, Nanchang, ChinaDepartment of General Surgery, Second Affiliated Hospital of Nanchang University, Nanchang, China; Jiangxi Province Medical College of Nanchang University, Nanchang, ChinaDepartment of General Surgery, Second Affiliated Hospital of Nanchang University, Nanchang, China; Jiangxi Province Medical College of Nanchang University, Nanchang, ChinaDepartment of General Surgery, Second Affiliated Hospital of Nanchang University, Nanchang, China; Jiangxi Province Medical College of Nanchang University, Nanchang, ChinaDepartment of General Surgery, Second Affiliated Hospital of Nanchang University, Nanchang, China; Jiangxi Province Medical College of Nanchang University, Nanchang, ChinaDepartment of General Surgery, Second Affiliated Hospital of Nanchang University, Nanchang, China; Corresponding author: Zhengming Zhu, Department of General Surgery, Second Affiliation Hospital of Nanching University, Nanchang, China.The leading cause of death in pancreatic cancer (PC) patients is the progression of cancer metastasis. Recently, long non-coding RNAs (lncRNAs) have been shown to play an important role in regulating cancer cell proliferation and metastasis; however, its molecular basis in PC remains to be explored. In this study, we observed that LINC01094 was markedly overexpressed in PC tissues and was associated with poor patient prognosis. Downregulation of LINC01094 decreased the proliferation and metastasis of PC cells and inhibited tumorigenesis and metastasis in mouse xenografts. Mechanically, LINC01094 acted as an endogenous miR-577 sponge to increase the expression of its target gene, the RNA-binding protein lin-28 homolog B (LIN28B), by decoying the miR-577, thereby activating the PI3K/AKT pathway. Our findings suggest that LINC01094 plays critical roles in proliferation and metastasis of PC, implying that LINC01094 can be regarded as a new biomarker or therapeutic target for the treatment of PC.http://www.sciencedirect.com/science/article/pii/S2162253121002183LINC01094pancreatic cancermiR-577LIN28BPI3K/AKT pathwayproliferation |
| spellingShingle | Chen Luo Kang Lin Cegui Hu Xiaojian Zhu Jinfeng Zhu Zhengming Zhu LINC01094 promotes pancreatic cancer progression by sponging miR-577 to regulate LIN28B expression and the PI3K/AKT pathway Molecular Therapy: Nucleic Acids LINC01094 pancreatic cancer miR-577 LIN28B PI3K/AKT pathway proliferation |
| title | LINC01094 promotes pancreatic cancer progression by sponging miR-577 to regulate LIN28B expression and the PI3K/AKT pathway |
| title_full | LINC01094 promotes pancreatic cancer progression by sponging miR-577 to regulate LIN28B expression and the PI3K/AKT pathway |
| title_fullStr | LINC01094 promotes pancreatic cancer progression by sponging miR-577 to regulate LIN28B expression and the PI3K/AKT pathway |
| title_full_unstemmed | LINC01094 promotes pancreatic cancer progression by sponging miR-577 to regulate LIN28B expression and the PI3K/AKT pathway |
| title_short | LINC01094 promotes pancreatic cancer progression by sponging miR-577 to regulate LIN28B expression and the PI3K/AKT pathway |
| title_sort | linc01094 promotes pancreatic cancer progression by sponging mir 577 to regulate lin28b expression and the pi3k akt pathway |
| topic | LINC01094 pancreatic cancer miR-577 LIN28B PI3K/AKT pathway proliferation |
| url | http://www.sciencedirect.com/science/article/pii/S2162253121002183 |
| work_keys_str_mv | AT chenluo linc01094promotespancreaticcancerprogressionbyspongingmir577toregulatelin28bexpressionandthepi3kaktpathway AT kanglin linc01094promotespancreaticcancerprogressionbyspongingmir577toregulatelin28bexpressionandthepi3kaktpathway AT ceguihu linc01094promotespancreaticcancerprogressionbyspongingmir577toregulatelin28bexpressionandthepi3kaktpathway AT xiaojianzhu linc01094promotespancreaticcancerprogressionbyspongingmir577toregulatelin28bexpressionandthepi3kaktpathway AT jinfengzhu linc01094promotespancreaticcancerprogressionbyspongingmir577toregulatelin28bexpressionandthepi3kaktpathway AT zhengmingzhu linc01094promotespancreaticcancerprogressionbyspongingmir577toregulatelin28bexpressionandthepi3kaktpathway |