Cytokine Directed Chondroblast Trans-Differentiation: <i>JAK</i> Inhibition Facilitates Direct Reprogramming of Fibroblasts to Chondroblasts

Cytokine Directed Chondroblast Trans-Differentiation: <i>JAK</i> Inhibition Facilitates Direct Reprogramming of Fibroblasts to Chondroblasts

Osteoarthritis (OA) is a degenerative disease of the hyaline articular cartilage. This disease is progressive and may lead to disability. Researchers proposed many regenerative approaches to treat osteoarthritis, including stem cells. Trans-differentiation of a fully differentiated cell state direct...

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Bibliographic Details
Main Authors: Perla Cota, Summer A. Helmi, Charlie Hsu, Derrick E. Rancourt
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cells
Subjects:
trans-differentiation
osteoarthritis
cartilage regeneration
cellular reprogramming
Online Access:https://www.mdpi.com/2073-4409/9/1/191

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