The role of insulin as a key regulator of seeding, proliferation, and mRNA transcription of human pluripotent stem cells

The role of insulin as a key regulator of seeding, proliferation, and mRNA transcription of human pluripotent stem cells

Abstract Background Human-induced pluripotent stem cells (hiPSCs) show a great promise as a renewable source of cells with broad biomedical applications. Since insulin has been used in the maintenance of hiPSCs, in this study we explored the role of insulin in culture of these cells. Methods We repo...

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Bibliographic Details
Main Authors: Mohammad Shahbazi, Paige Cundiff, Wenyu Zhou, Philip Lee, Achchhe Patel, Sunita L. D’Souza, Fahim Abbasi, Thomas Quertermous, Joshua W. Knowles
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Stem Cell Research & Therapy
Subjects:
Insulin
Insulin signaling
Proliferation
Apoptosis
Pluripotent stem cells
Transcriptional regulation
Online Access:http://link.springer.com/article/10.1186/s13287-019-1319-5

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