High Prolactin Concentration Induces Ovarian Granulosa Cell Oxidative Stress, Leading to Apoptosis Mediated by <i>L-PRLR</i> and <i>S-PRLR</i>

High Prolactin Concentration Induces Ovarian Granulosa Cell Oxidative Stress, Leading to Apoptosis Mediated by <i>L-PRLR</i> and <i>S-PRLR</i>

High prolactin (PRL) concentration has been shown to induce the apoptosis of ovine ovarian granulosa cells (GCs), but the underlying mechanisms are unclear. This study aimed to investigate the mechanism of apoptosis induced by high PRL concentration in GCs. Trial 1: The optimal concentration of glut...

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Bibliographic Details
Main Authors: Ruochen Yang, Chunhui Duan, Shuo Zhang, Yunxia Guo, Xinyu Shan, Meijing Chen, Sicong Yue, Yingjie Zhang, Yueqin Liu
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Molecular Sciences
Subjects:
ovine ovarian GCs
apoptosis
oxidative stress
autophagy
mitochondria
ROS
Online Access:https://www.mdpi.com/1422-0067/24/19/14407

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