Application of Thermal Analysis to Evaluate Pharmaceutical Preparations Containing Theophylline
Confirmation of the composition of pharmaceutical products is an essential pharmaceutical issue. The purity and identity of active pharmaceutical ingredients (API) in the finished drug impact the effect of correct and safe pharmacotherapy. The currently frequently used advanced analytical methods ar...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/15/10/1268 |
| _version_ | 1797470462916165632 |
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| author | Paweł Ramos |
| author_facet | Paweł Ramos |
| author_sort | Paweł Ramos |
| collection | DOAJ |
| description | Confirmation of the composition of pharmaceutical products is an essential pharmaceutical issue. The purity and identity of active pharmaceutical ingredients (API) in the finished drug impact the effect of correct and safe pharmacotherapy. The currently frequently used advanced analytical methods are laborious and time-consuming. On the other hand, less advanced techniques such as UV-Vis spectrophotometry are less specific. In the presented study, thermogravimetry analysis (TGA)—supported by calculated differential thermal analysis (c-DTA)—was proposed to evaluate the composition of pharmaceutical preparations containing theophylline and aminophylline. Due to its advantages, the TGA method can be an alternative used for screening assessment of the composition of pharmaceutical preparations. The obtained results show that TGA supported by c-DTA is a suitable screening method for assessing the composition of pharmaceutical preparations containing theophylline and aminophylline. Both thermal techniques complement each other to obtain reliable results. In contrast to the pharmacopoeial UV-Vis method, TGA allows for unambiguous identification and distinction of one- and two-component pharmaceutical preparations. Moreover, thanks to TGA and c-DTA, it was possible to identify the excipient used in the formulation of a commercial drug and to detect considerable amounts of lactose in the experimentally prepared counterfeit formulation. The research herein indicates the multifaceted application and usefulness of TGA and c-DTA in pharmacology. |
| first_indexed | 2024-03-09T19:36:36Z |
| format | Article |
| id | doaj.art-738f7a2d65ce48e6a8dc5ab948ee1d42 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T19:36:36Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-738f7a2d65ce48e6a8dc5ab948ee1d422023-11-24T01:52:16ZengMDPI AGPharmaceuticals1424-82472022-10-011510126810.3390/ph15101268Application of Thermal Analysis to Evaluate Pharmaceutical Preparations Containing TheophyllinePaweł Ramos0Department of Biophysics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Jedności 8, 41-200 Sosnowiec, PolandConfirmation of the composition of pharmaceutical products is an essential pharmaceutical issue. The purity and identity of active pharmaceutical ingredients (API) in the finished drug impact the effect of correct and safe pharmacotherapy. The currently frequently used advanced analytical methods are laborious and time-consuming. On the other hand, less advanced techniques such as UV-Vis spectrophotometry are less specific. In the presented study, thermogravimetry analysis (TGA)—supported by calculated differential thermal analysis (c-DTA)—was proposed to evaluate the composition of pharmaceutical preparations containing theophylline and aminophylline. Due to its advantages, the TGA method can be an alternative used for screening assessment of the composition of pharmaceutical preparations. The obtained results show that TGA supported by c-DTA is a suitable screening method for assessing the composition of pharmaceutical preparations containing theophylline and aminophylline. Both thermal techniques complement each other to obtain reliable results. In contrast to the pharmacopoeial UV-Vis method, TGA allows for unambiguous identification and distinction of one- and two-component pharmaceutical preparations. Moreover, thanks to TGA and c-DTA, it was possible to identify the excipient used in the formulation of a commercial drug and to detect considerable amounts of lactose in the experimentally prepared counterfeit formulation. The research herein indicates the multifaceted application and usefulness of TGA and c-DTA in pharmacology.https://www.mdpi.com/1424-8247/15/10/1268theophyllineaminophyllineTGAc-DTAUV spectrophotometrypharmaceutical preparation |
| spellingShingle | Paweł Ramos Application of Thermal Analysis to Evaluate Pharmaceutical Preparations Containing Theophylline Pharmaceuticals theophylline aminophylline TGA c-DTA UV spectrophotometry pharmaceutical preparation |
| title | Application of Thermal Analysis to Evaluate Pharmaceutical Preparations Containing Theophylline |
| title_full | Application of Thermal Analysis to Evaluate Pharmaceutical Preparations Containing Theophylline |
| title_fullStr | Application of Thermal Analysis to Evaluate Pharmaceutical Preparations Containing Theophylline |
| title_full_unstemmed | Application of Thermal Analysis to Evaluate Pharmaceutical Preparations Containing Theophylline |
| title_short | Application of Thermal Analysis to Evaluate Pharmaceutical Preparations Containing Theophylline |
| title_sort | application of thermal analysis to evaluate pharmaceutical preparations containing theophylline |
| topic | theophylline aminophylline TGA c-DTA UV spectrophotometry pharmaceutical preparation |
| url | https://www.mdpi.com/1424-8247/15/10/1268 |
| work_keys_str_mv | AT pawełramos applicationofthermalanalysistoevaluatepharmaceuticalpreparationscontainingtheophylline |