Efficient solid-phase synthesis of 1,2,3-benzotriazin-4-ones with SynPhaseTM Lanterns
We have developed a solid-phase synthesis of 1,2,3-benzotriazin-4-ones through cyclization of 2-aminobenzamides via diazotization. The development of an efficient synthesis is important from the viewpoint of drug discovery, considering the various bioactivities of these derivatives. The precursors o...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2003-01-01
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| Series: | Journal of the Brazilian Chemical Society |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532003000300019 |
| _version_ | 1818042083889381376 |
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| author | Makino Shingo Nakanishi Eiji Tsuji Takashi |
| author_facet | Makino Shingo Nakanishi Eiji Tsuji Takashi |
| author_sort | Makino Shingo |
| collection | DOAJ |
| description | We have developed a solid-phase synthesis of 1,2,3-benzotriazin-4-ones through cyclization of 2-aminobenzamides via diazotization. The development of an efficient synthesis is important from the viewpoint of drug discovery, considering the various bioactivities of these derivatives. The precursors of 1,2,3-benzotriazin-4-ones, 2-aminobenzamides, were prepared from solid-supported amines and 2-nitrobenzoic acids. Various 1,2,3-benzotriazin-4-ones were obtained with high purity using SynPhaseTM Lanterns. |
| first_indexed | 2024-12-10T08:40:41Z |
| format | Article |
| id | doaj.art-7391d014e74c4afdb4ffc93ebd9c168f |
| institution | Directory Open Access Journal |
| issn | 0103-5053 |
| language | English |
| last_indexed | 2024-12-10T08:40:41Z |
| publishDate | 2003-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Journal of the Brazilian Chemical Society |
| spelling | doaj.art-7391d014e74c4afdb4ffc93ebd9c168f2022-12-22T01:55:51ZengSociedade Brasileira de QuímicaJournal of the Brazilian Chemical Society0103-50532003-01-01143452455Efficient solid-phase synthesis of 1,2,3-benzotriazin-4-ones with SynPhaseTM LanternsMakino ShingoNakanishi EijiTsuji TakashiWe have developed a solid-phase synthesis of 1,2,3-benzotriazin-4-ones through cyclization of 2-aminobenzamides via diazotization. The development of an efficient synthesis is important from the viewpoint of drug discovery, considering the various bioactivities of these derivatives. The precursors of 1,2,3-benzotriazin-4-ones, 2-aminobenzamides, were prepared from solid-supported amines and 2-nitrobenzoic acids. Various 1,2,3-benzotriazin-4-ones were obtained with high purity using SynPhaseTM Lanterns.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532003000300019solid-phase synthesisdrugquinazoline1,2,3-benzotriazin-4-oneSynPhaseTM Lanterndiazotization |
| spellingShingle | Makino Shingo Nakanishi Eiji Tsuji Takashi Efficient solid-phase synthesis of 1,2,3-benzotriazin-4-ones with SynPhaseTM Lanterns Journal of the Brazilian Chemical Society solid-phase synthesis drug quinazoline 1,2,3-benzotriazin-4-one SynPhaseTM Lantern diazotization |
| title | Efficient solid-phase synthesis of 1,2,3-benzotriazin-4-ones with SynPhaseTM Lanterns |
| title_full | Efficient solid-phase synthesis of 1,2,3-benzotriazin-4-ones with SynPhaseTM Lanterns |
| title_fullStr | Efficient solid-phase synthesis of 1,2,3-benzotriazin-4-ones with SynPhaseTM Lanterns |
| title_full_unstemmed | Efficient solid-phase synthesis of 1,2,3-benzotriazin-4-ones with SynPhaseTM Lanterns |
| title_short | Efficient solid-phase synthesis of 1,2,3-benzotriazin-4-ones with SynPhaseTM Lanterns |
| title_sort | efficient solid phase synthesis of 1 2 3 benzotriazin 4 ones with synphasetm lanterns |
| topic | solid-phase synthesis drug quinazoline 1,2,3-benzotriazin-4-one SynPhaseTM Lantern diazotization |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532003000300019 |
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