Education, tobacco smoking, alcohol consumption, and IL-2 and IL-6 gene polymorphisms in the survival of head and neck cancer
The association of education, tobacco smoking, alcohol consumption, and interleukin-2 (IL-2 +114 and -384) and -6 (IL-6 -174) DNA polymorphisms with head and neck squamous cell carcinoma (HNSCC) was investigated in a cohort study of 445 subjects. IL-2 and IL-6 genotypes were determined by real-time...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2011-10-01
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| Series: | Brazilian Journal of Medical and Biological Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001000005 |
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| author | R.V.M. López M.A. Zago J. Eluf-Neto M.P. Curado A.W. Daudt W.A. da Silva-Junior D.L. Zanette J.E. Levi M.B. de Carvalho L.P. Kowalski M. Abrahão J.F. de Góis-Filho P. Boffetta V. Wünsch-Filho |
| author_facet | R.V.M. López M.A. Zago J. Eluf-Neto M.P. Curado A.W. Daudt W.A. da Silva-Junior D.L. Zanette J.E. Levi M.B. de Carvalho L.P. Kowalski M. Abrahão J.F. de Góis-Filho P. Boffetta V. Wünsch-Filho |
| author_sort | R.V.M. López |
| collection | DOAJ |
| description | The association of education, tobacco smoking, alcohol consumption, and interleukin-2 (IL-2 +114 and -384) and -6 (IL-6 -174) DNA polymorphisms with head and neck squamous cell carcinoma (HNSCC) was investigated in a cohort study of 445 subjects. IL-2 and IL-6 genotypes were determined by real-time PCR. Cox regression was used to estimate hazard ratios (HR) and 95% confidence intervals (95%CI) of disease-specific survival according to anatomical sites of the head and neck. Mean age was 56 years and most patients were males (87.6%). Subjects with 5 or more years of schooling had better survival in larynx cancer. Smoking had no effect on HNSCC survival, but alcohol consumption had a statistically significant effect on larynx cancer. IL-2 gene +114 G/T (HR = 0.52; 95%CI = 0.15-1.81) and T/T (HR = 0.22; 95%CI = 0.02-3.19) genotypes were associated with better survival in hypopharynx cancer. IL-2 +114 G/T was a predictor of poor survival in oral cavity/oropharynx cancer and larynx cancer (HR = 1.32; 95%CI = 0.61-2.85). IL-2 -384 G/T was associated with better survival in oral cavity/oropharynx cancer (HR = 0.80; 95%CI = 0.45-1.42) and hypopharynx cancer (HR = 0.68; 95%CI = 0.21-2.20), but an inverse relationship was observed for larynx cancer. IL-6 -174 G/C was associated with better survival in hypopharynx cancer (HR = 0.68; 95%CI = 0.26-1.78) and larynx cancer (HR = 0.93; 95%CI = 0.42-2.07), and C/C reduced mortality in larynx cancer. In general, our results are similar to previous reports on the value of education, smoking, alcohol consumption, and IL-2 and IL-6 genetic polymorphisms for the prognosis of HNSCC, but the risks due to these variables are small and estimates imprecise. |
| first_indexed | 2024-12-13T02:58:06Z |
| format | Article |
| id | doaj.art-7392949014a1461499a782b62b82122c |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-13T02:58:06Z |
| publishDate | 2011-10-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-7392949014a1461499a782b62b82122c2022-12-22T00:01:55ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2011-10-01441010061012Education, tobacco smoking, alcohol consumption, and IL-2 and IL-6 gene polymorphisms in the survival of head and neck cancerR.V.M. LópezM.A. ZagoJ. Eluf-NetoM.P. CuradoA.W. DaudtW.A. da Silva-JuniorD.L. ZanetteJ.E. LeviM.B. de CarvalhoL.P. KowalskiM. AbrahãoJ.F. de Góis-FilhoP. BoffettaV. Wünsch-FilhoThe association of education, tobacco smoking, alcohol consumption, and interleukin-2 (IL-2 +114 and -384) and -6 (IL-6 -174) DNA polymorphisms with head and neck squamous cell carcinoma (HNSCC) was investigated in a cohort study of 445 subjects. IL-2 and IL-6 genotypes were determined by real-time PCR. Cox regression was used to estimate hazard ratios (HR) and 95% confidence intervals (95%CI) of disease-specific survival according to anatomical sites of the head and neck. Mean age was 56 years and most patients were males (87.6%). Subjects with 5 or more years of schooling had better survival in larynx cancer. Smoking had no effect on HNSCC survival, but alcohol consumption had a statistically significant effect on larynx cancer. IL-2 gene +114 G/T (HR = 0.52; 95%CI = 0.15-1.81) and T/T (HR = 0.22; 95%CI = 0.02-3.19) genotypes were associated with better survival in hypopharynx cancer. IL-2 +114 G/T was a predictor of poor survival in oral cavity/oropharynx cancer and larynx cancer (HR = 1.32; 95%CI = 0.61-2.85). IL-2 -384 G/T was associated with better survival in oral cavity/oropharynx cancer (HR = 0.80; 95%CI = 0.45-1.42) and hypopharynx cancer (HR = 0.68; 95%CI = 0.21-2.20), but an inverse relationship was observed for larynx cancer. IL-6 -174 G/C was associated with better survival in hypopharynx cancer (HR = 0.68; 95%CI = 0.26-1.78) and larynx cancer (HR = 0.93; 95%CI = 0.42-2.07), and C/C reduced mortality in larynx cancer. In general, our results are similar to previous reports on the value of education, smoking, alcohol consumption, and IL-2 and IL-6 genetic polymorphisms for the prognosis of HNSCC, but the risks due to these variables are small and estimates imprecise.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001000005SmokingAlcoholInterleukinHead and neck cancerCancer prognosisSurvival analysis |
| spellingShingle | R.V.M. López M.A. Zago J. Eluf-Neto M.P. Curado A.W. Daudt W.A. da Silva-Junior D.L. Zanette J.E. Levi M.B. de Carvalho L.P. Kowalski M. Abrahão J.F. de Góis-Filho P. Boffetta V. Wünsch-Filho Education, tobacco smoking, alcohol consumption, and IL-2 and IL-6 gene polymorphisms in the survival of head and neck cancer Brazilian Journal of Medical and Biological Research Smoking Alcohol Interleukin Head and neck cancer Cancer prognosis Survival analysis |
| title | Education, tobacco smoking, alcohol consumption, and IL-2 and IL-6 gene polymorphisms in the survival of head and neck cancer |
| title_full | Education, tobacco smoking, alcohol consumption, and IL-2 and IL-6 gene polymorphisms in the survival of head and neck cancer |
| title_fullStr | Education, tobacco smoking, alcohol consumption, and IL-2 and IL-6 gene polymorphisms in the survival of head and neck cancer |
| title_full_unstemmed | Education, tobacco smoking, alcohol consumption, and IL-2 and IL-6 gene polymorphisms in the survival of head and neck cancer |
| title_short | Education, tobacco smoking, alcohol consumption, and IL-2 and IL-6 gene polymorphisms in the survival of head and neck cancer |
| title_sort | education tobacco smoking alcohol consumption and il 2 and il 6 gene polymorphisms in the survival of head and neck cancer |
| topic | Smoking Alcohol Interleukin Head and neck cancer Cancer prognosis Survival analysis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001000005 |
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