Effect of Alcoholic Intoxication on the Risk of Inflammatory Bowel Disease: A Nationwide Retrospective Cohort Study.
This study investigated whether alcoholic intoxication (AI) increases the risk of inflammatory bowel disease (IBD) by using a population-based database in Taiwan.This retrospective matched-cohort study included 57 611 inpatients with new-onset AI (AI cohort) and 230 444 randomly selected controls (n...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5089729?pdf=render |
| _version_ | 1818480530828558336 |
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| author | Tai-Yi Hsu Hong-Mo Shih Yu-Chiao Wang Leng-Chieh Lin Guan-Yi He Chih-Yu Chen Chia-Hung Kao Chao-Hsien Chen Wei-Kung Chen Tse-Yen Yang |
| author_facet | Tai-Yi Hsu Hong-Mo Shih Yu-Chiao Wang Leng-Chieh Lin Guan-Yi He Chih-Yu Chen Chia-Hung Kao Chao-Hsien Chen Wei-Kung Chen Tse-Yen Yang |
| author_sort | Tai-Yi Hsu |
| collection | DOAJ |
| description | This study investigated whether alcoholic intoxication (AI) increases the risk of inflammatory bowel disease (IBD) by using a population-based database in Taiwan.This retrospective matched-cohort study included 57 611 inpatients with new-onset AI (AI cohort) and 230 444 randomly selected controls (non-AI cohort). Each patient was monitored for 10 years to individually identify those who were subsequently diagnosed with Crohn disease (CD) and ulcerative colitis (UC) during the follow-up period. Cox proportional hazard regression analysis was conducted to determine the risk of IBD in patients with AI compared with controls without AI.The incidence rate of IBD during the 10-year follow-up period was 2.69 per 1 000 person-years and 0.49 per 1 000 person-years in the AI and non-AI cohorts, respectively. After adjustment for age, sex, and comorbidity, the AI cohort exhibited a 3.17-fold increased risk of IBD compared with the non-AI cohort (hazard ratio [HR] = 3.17, 95% confidence interval [CI] = 2.19-4.58). Compared with the non-AI cohort, the HRs of CD and UC were 4.40 and 2.33 for the AI cohort, respectively. After stratification for the severity of AI according to the duration of hospital stay, the adjusted HRs exhibited a significant correlation with the severity; the HRs of IBD were 1.76, 6.83, and 19.9 for patients with mild, moderate, and severe AI, respectively (p for the trend < .0001).The risk of IBD was higher in patients with AI and increased with the length of hospital stay. |
| first_indexed | 2024-12-10T11:24:54Z |
| format | Article |
| id | doaj.art-73952cbb772849c8940562b181e04634 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T11:24:54Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-73952cbb772849c8940562b181e046342022-12-22T01:50:46ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011111e016541110.1371/journal.pone.0165411Effect of Alcoholic Intoxication on the Risk of Inflammatory Bowel Disease: A Nationwide Retrospective Cohort Study.Tai-Yi HsuHong-Mo ShihYu-Chiao WangLeng-Chieh LinGuan-Yi HeChih-Yu ChenChia-Hung KaoChao-Hsien ChenWei-Kung ChenTse-Yen YangThis study investigated whether alcoholic intoxication (AI) increases the risk of inflammatory bowel disease (IBD) by using a population-based database in Taiwan.This retrospective matched-cohort study included 57 611 inpatients with new-onset AI (AI cohort) and 230 444 randomly selected controls (non-AI cohort). Each patient was monitored for 10 years to individually identify those who were subsequently diagnosed with Crohn disease (CD) and ulcerative colitis (UC) during the follow-up period. Cox proportional hazard regression analysis was conducted to determine the risk of IBD in patients with AI compared with controls without AI.The incidence rate of IBD during the 10-year follow-up period was 2.69 per 1 000 person-years and 0.49 per 1 000 person-years in the AI and non-AI cohorts, respectively. After adjustment for age, sex, and comorbidity, the AI cohort exhibited a 3.17-fold increased risk of IBD compared with the non-AI cohort (hazard ratio [HR] = 3.17, 95% confidence interval [CI] = 2.19-4.58). Compared with the non-AI cohort, the HRs of CD and UC were 4.40 and 2.33 for the AI cohort, respectively. After stratification for the severity of AI according to the duration of hospital stay, the adjusted HRs exhibited a significant correlation with the severity; the HRs of IBD were 1.76, 6.83, and 19.9 for patients with mild, moderate, and severe AI, respectively (p for the trend < .0001).The risk of IBD was higher in patients with AI and increased with the length of hospital stay.http://europepmc.org/articles/PMC5089729?pdf=render |
| spellingShingle | Tai-Yi Hsu Hong-Mo Shih Yu-Chiao Wang Leng-Chieh Lin Guan-Yi He Chih-Yu Chen Chia-Hung Kao Chao-Hsien Chen Wei-Kung Chen Tse-Yen Yang Effect of Alcoholic Intoxication on the Risk of Inflammatory Bowel Disease: A Nationwide Retrospective Cohort Study. PLoS ONE |
| title | Effect of Alcoholic Intoxication on the Risk of Inflammatory Bowel Disease: A Nationwide Retrospective Cohort Study. |
| title_full | Effect of Alcoholic Intoxication on the Risk of Inflammatory Bowel Disease: A Nationwide Retrospective Cohort Study. |
| title_fullStr | Effect of Alcoholic Intoxication on the Risk of Inflammatory Bowel Disease: A Nationwide Retrospective Cohort Study. |
| title_full_unstemmed | Effect of Alcoholic Intoxication on the Risk of Inflammatory Bowel Disease: A Nationwide Retrospective Cohort Study. |
| title_short | Effect of Alcoholic Intoxication on the Risk of Inflammatory Bowel Disease: A Nationwide Retrospective Cohort Study. |
| title_sort | effect of alcoholic intoxication on the risk of inflammatory bowel disease a nationwide retrospective cohort study |
| url | http://europepmc.org/articles/PMC5089729?pdf=render |
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