Utilizing cell-free DNA to validate targeted disruption of MYO7A in rhesus macaque pre-implantation embryos

Utilizing cell-free DNA to validate targeted disruption of MYO7A in rhesus macaque pre-implantation embryos

Direct injection of CRISPR/Cas9 into zygotes enables the production of genetically modified nonhuman primates (NHPs) essential for modeling specific human diseases, such as Usher syndrome, and for developing novel therapeutic strategies. Usher syndrome is a rare genetic disease that causes loss of h...

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Bibliographic Details
Main Authors: Junghyun Ryu, Fernanda C. Burch, Emily Mishler, Martha Neuringer, Jon D. Hennebold, Carol Hanna
Format: Article
Language:English
Published: The Korean Society of Animal Reproduction and Biotechnology 2022-12-01
Series:Journal of Animal Reproduction and Biotechnology
Subjects:
cell-free dna
crispr/cas9
knockout
myo7a
usher syndrome
Online Access:https://www.e-jarb.org/journal/view.html?uid=2639&vmd=Full

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