Extracorporeal Photopheresis in Dermatological Diseases
Extracorporeal photopheresis (ECP) is an apheresis procedure that is conventionally used as a first-line treatment for cutaneous and leukemic subtypes of T-cell lymphoma, such as Sezary’s syndrome and mycosis fungoides. Over the past three decades, its immunotherapeutic properties have been tested o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/5/3011 |
| _version_ | 1797264366201995264 |
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| author | Hanna Terhaar Mohammad Saleem Nabiha Yusuf |
| author_facet | Hanna Terhaar Mohammad Saleem Nabiha Yusuf |
| author_sort | Hanna Terhaar |
| collection | DOAJ |
| description | Extracorporeal photopheresis (ECP) is an apheresis procedure that is conventionally used as a first-line treatment for cutaneous and leukemic subtypes of T-cell lymphoma, such as Sezary’s syndrome and mycosis fungoides. Over the past three decades, its immunotherapeutic properties have been tested on a variety of autoimmune conditions, including many dermatologic diseases. There is ample evidence of ECP’s ability to modify leukocytes and alter cytokine production for certain dermatologic diseases that have been refractory to first-line treatments, such as atopic dermatitis. However, the evidence on the efficacy of ECP for the treatment of these dermatologic diseases is unclear and/or lacks sufficient evidence. The purpose of this paper is to review the literature on the utilization and clinical efficacy of ECP in the treatment of several [autoimmune] dermatologic diseases and discuss its applications, guidelines, recommendations, and future implementation for dermatologic diseases. |
| first_indexed | 2024-04-25T00:27:45Z |
| format | Article |
| id | doaj.art-739645da725c48d58a2d3ba4bc846a64 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-04-25T00:27:45Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-739645da725c48d58a2d3ba4bc846a642024-03-12T16:47:15ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-03-01255301110.3390/ijms25053011Extracorporeal Photopheresis in Dermatological DiseasesHanna Terhaar0Mohammad Saleem1Nabiha Yusuf2Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USADepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USADepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USAExtracorporeal photopheresis (ECP) is an apheresis procedure that is conventionally used as a first-line treatment for cutaneous and leukemic subtypes of T-cell lymphoma, such as Sezary’s syndrome and mycosis fungoides. Over the past three decades, its immunotherapeutic properties have been tested on a variety of autoimmune conditions, including many dermatologic diseases. There is ample evidence of ECP’s ability to modify leukocytes and alter cytokine production for certain dermatologic diseases that have been refractory to first-line treatments, such as atopic dermatitis. However, the evidence on the efficacy of ECP for the treatment of these dermatologic diseases is unclear and/or lacks sufficient evidence. The purpose of this paper is to review the literature on the utilization and clinical efficacy of ECP in the treatment of several [autoimmune] dermatologic diseases and discuss its applications, guidelines, recommendations, and future implementation for dermatologic diseases.https://www.mdpi.com/1422-0067/25/5/3011extracorporeal photopheresisextracorporeal photochemotherapyautoimmune skin diseasesimmunotherapydermatologic diseases |
| spellingShingle | Hanna Terhaar Mohammad Saleem Nabiha Yusuf Extracorporeal Photopheresis in Dermatological Diseases International Journal of Molecular Sciences extracorporeal photopheresis extracorporeal photochemotherapy autoimmune skin diseases immunotherapy dermatologic diseases |
| title | Extracorporeal Photopheresis in Dermatological Diseases |
| title_full | Extracorporeal Photopheresis in Dermatological Diseases |
| title_fullStr | Extracorporeal Photopheresis in Dermatological Diseases |
| title_full_unstemmed | Extracorporeal Photopheresis in Dermatological Diseases |
| title_short | Extracorporeal Photopheresis in Dermatological Diseases |
| title_sort | extracorporeal photopheresis in dermatological diseases |
| topic | extracorporeal photopheresis extracorporeal photochemotherapy autoimmune skin diseases immunotherapy dermatologic diseases |
| url | https://www.mdpi.com/1422-0067/25/5/3011 |
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