BONE MINERAL DENSITY IN SJOGREN'S DISEASE
Objective. To study mineral density of bone tissue (BMD) in female pts with Sjogren's syndrome (SS) depending on menstrual statute and to evaluate the effect on it of long-term (for 5 years and more) therapy by prednizolone in dosage 2.5-5 mg/day on the state of bone tissue. Material and method...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2002-06-01
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| Series: | Научно-практическая ревматология |
| Subjects: | |
| Online Access: | https://rsp.mediar-press.net/rsp/article/view/1118 |
| _version_ | 1797863060782710784 |
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| author | N S Sliornikova V I Vassiliev A V Smirnov |
| author_facet | N S Sliornikova V I Vassiliev A V Smirnov |
| author_sort | N S Sliornikova |
| collection | DOAJ |
| description | Objective. To study mineral density of bone tissue (BMD) in female pts with Sjogren's syndrome (SS) depending on menstrual statute and to evaluate the effect on it of long-term (for 5 years and more) therapy by prednizolone in dosage 2.5-5 mg/day on the state of bone tissue. Material and methods. 120 female pts aged 30-63 were examined by densitometry of low back and femoral neck with «Hologic 1000». Results. Comparison of obtained results with reference base data enabled to reveal negative effect of prednizolo- nc on bone tissue mineralization, clearly demonstrated at the beginning of glucocorticosteroid therapy in peri- menopausa. It was also noted that menopausa began earlier in pts taking prednizolone (at 43.9±5.1 y/o) as compared with untreated ones (at 4S.9±4.5 y/o); there were notable effect of the age of menopausa beginning on BMD and lower effect of the duration of postmenopausa. Rare (3.3%) development of osteoporosis in women of reproductive age associated with long-term non-correctable hypergammaglobulinemia and damage of renal tubular apparatus. |
| first_indexed | 2024-04-09T22:29:31Z |
| format | Article |
| id | doaj.art-7397c84f17f84646b9699d413a0df901 |
| institution | Directory Open Access Journal |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| last_indexed | 2024-04-09T22:29:31Z |
| publishDate | 2002-06-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj.art-7397c84f17f84646b9699d413a0df9012023-03-22T13:45:38ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922002-06-0140381210.14412/1995-4484-2002-12081058BONE MINERAL DENSITY IN SJOGREN'S DISEASEN S SliornikovaV I VassilievA V SmirnovObjective. To study mineral density of bone tissue (BMD) in female pts with Sjogren's syndrome (SS) depending on menstrual statute and to evaluate the effect on it of long-term (for 5 years and more) therapy by prednizolone in dosage 2.5-5 mg/day on the state of bone tissue. Material and methods. 120 female pts aged 30-63 were examined by densitometry of low back and femoral neck with «Hologic 1000». Results. Comparison of obtained results with reference base data enabled to reveal negative effect of prednizolo- nc on bone tissue mineralization, clearly demonstrated at the beginning of glucocorticosteroid therapy in peri- menopausa. It was also noted that menopausa began earlier in pts taking prednizolone (at 43.9±5.1 y/o) as compared with untreated ones (at 4S.9±4.5 y/o); there were notable effect of the age of menopausa beginning on BMD and lower effect of the duration of postmenopausa. Rare (3.3%) development of osteoporosis in women of reproductive age associated with long-term non-correctable hypergammaglobulinemia and damage of renal tubular apparatus.https://rsp.mediar-press.net/rsp/article/view/1118osteopeniahone mineral densitysideren’s disease |
| spellingShingle | N S Sliornikova V I Vassiliev A V Smirnov BONE MINERAL DENSITY IN SJOGREN'S DISEASE Научно-практическая ревматология osteopenia hone mineral density sideren’s disease |
| title | BONE MINERAL DENSITY IN SJOGREN'S DISEASE |
| title_full | BONE MINERAL DENSITY IN SJOGREN'S DISEASE |
| title_fullStr | BONE MINERAL DENSITY IN SJOGREN'S DISEASE |
| title_full_unstemmed | BONE MINERAL DENSITY IN SJOGREN'S DISEASE |
| title_short | BONE MINERAL DENSITY IN SJOGREN'S DISEASE |
| title_sort | bone mineral density in sjogren s disease |
| topic | osteopenia hone mineral density sideren’s disease |
| url | https://rsp.mediar-press.net/rsp/article/view/1118 |
| work_keys_str_mv | AT nssliornikova bonemineraldensityinsjogrensdisease AT vivassiliev bonemineraldensityinsjogrensdisease AT avsmirnov bonemineraldensityinsjogrensdisease |