Body mass index, weight change, and risk of second primary breast cancer in the WECARE study: influence of estrogen receptor status of the first breast cancer
Abstract Studies examining the relationship between body mass index (BMI) and risk of contralateral breast cancer (CBC) have reported mixed findings. We previously showed that obese postmenopausal women with estrogen receptor (ER)‐negative breast cancer have a fivefold higher risk of CBC compared wi...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-11-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.890 |
| _version_ | 1818864235748261888 |
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| author | Jennifer D. Brooks Esther M. John Lene Mellemkjær Charles F. Lynch Julia A. Knight Kathleen E. Malone Anne S. Reiner Leslie Bernstein Xiaolin Liang Roy E. Shore Marilyn Stovall WECARE Study Collaborative Group Jonine L. Bernstein |
| author_facet | Jennifer D. Brooks Esther M. John Lene Mellemkjær Charles F. Lynch Julia A. Knight Kathleen E. Malone Anne S. Reiner Leslie Bernstein Xiaolin Liang Roy E. Shore Marilyn Stovall WECARE Study Collaborative Group Jonine L. Bernstein |
| author_sort | Jennifer D. Brooks |
| collection | DOAJ |
| description | Abstract Studies examining the relationship between body mass index (BMI) and risk of contralateral breast cancer (CBC) have reported mixed findings. We previously showed that obese postmenopausal women with estrogen receptor (ER)‐negative breast cancer have a fivefold higher risk of CBC compared with normal weight women. In the current analysis, we reexamined this relationship in the expanded Women's Environmental Cancer and Radiation Epidemiology (WECARE) Study, focusing on the impact of menopausal status and ER status of the first breast cancer. The WECARE Study is a population‐based case–control study of young women with CBC (cases, N = 1386) and with unilateral breast cancer (controls, N = 2045). Rate ratios (RR) and 95% confidence intervals (CI) were calculated to assess the relationship between BMI and risk of CBC stratified by menopausal and ER status. Positive associations with obesity and weight gain were limited to women who became postmenopausal following their first primary breast cancer. Among those with an ER‐negative first breast cancer, obesity (vs. normal weight) at first diagnosis was associated with an increased risk of CBC (RR = 1.9, 95% CI: 1.02, 3.4). Also, weight gain of ≥10 kg after first diagnosis was associated with an almost twofold increased risk of CBC (RR = 1.9, 95% CI: 0.99, 3.8). These results suggest that women with an ER‐negative first primary cancer who are obese at first primary diagnosis or who experience a large weight gain afterward may benefit from heightened surveillance. Future studies are needed to address the impact of weight loss interventions on risk of CBC. |
| first_indexed | 2024-12-19T10:28:26Z |
| format | Article |
| id | doaj.art-73983d975c194e159bb24c595caf1867 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-12-19T10:28:26Z |
| publishDate | 2016-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-73983d975c194e159bb24c595caf18672022-12-21T20:25:49ZengWileyCancer Medicine2045-76342016-11-015113282329110.1002/cam4.890Body mass index, weight change, and risk of second primary breast cancer in the WECARE study: influence of estrogen receptor status of the first breast cancerJennifer D. Brooks0Esther M. John1Lene Mellemkjær2Charles F. Lynch3Julia A. Knight4Kathleen E. Malone5Anne S. Reiner6Leslie Bernstein7Xiaolin Liang8Roy E. Shore9Marilyn Stovall10WECARE Study Collaborative GroupJonine L. Bernstein11University of Toronto Dalla Lana School of Public Health Sciences Toronto CanadaCancer Prevention Institute of California Fremont CaliforniaDanish Cancer Society Research Center Copenhagen DenmarkUniversity of Iowa Iowa City IowaUniversity of Toronto Dalla Lana School of Public Health Sciences Toronto CanadaFred Hutchinson Cancer Research Center Seattle WashingtonMemorial Sloan Kettering Cancer Center New York New YorkBeckman Research Institute City of Hope National Medical Center Duarte CaliforniaMemorial Sloan Kettering Cancer Center New York New YorkDepartment of Population Health New York University School of Medicine New York New YorkThe University of Texas MD Anderson Cancer Center Houston TexasMemorial Sloan Kettering Cancer Center New York New YorkAbstract Studies examining the relationship between body mass index (BMI) and risk of contralateral breast cancer (CBC) have reported mixed findings. We previously showed that obese postmenopausal women with estrogen receptor (ER)‐negative breast cancer have a fivefold higher risk of CBC compared with normal weight women. In the current analysis, we reexamined this relationship in the expanded Women's Environmental Cancer and Radiation Epidemiology (WECARE) Study, focusing on the impact of menopausal status and ER status of the first breast cancer. The WECARE Study is a population‐based case–control study of young women with CBC (cases, N = 1386) and with unilateral breast cancer (controls, N = 2045). Rate ratios (RR) and 95% confidence intervals (CI) were calculated to assess the relationship between BMI and risk of CBC stratified by menopausal and ER status. Positive associations with obesity and weight gain were limited to women who became postmenopausal following their first primary breast cancer. Among those with an ER‐negative first breast cancer, obesity (vs. normal weight) at first diagnosis was associated with an increased risk of CBC (RR = 1.9, 95% CI: 1.02, 3.4). Also, weight gain of ≥10 kg after first diagnosis was associated with an almost twofold increased risk of CBC (RR = 1.9, 95% CI: 0.99, 3.8). These results suggest that women with an ER‐negative first primary cancer who are obese at first primary diagnosis or who experience a large weight gain afterward may benefit from heightened surveillance. Future studies are needed to address the impact of weight loss interventions on risk of CBC.https://doi.org/10.1002/cam4.890Body mass indexcontralateral breast cancerestrogen receptor |
| spellingShingle | Jennifer D. Brooks Esther M. John Lene Mellemkjær Charles F. Lynch Julia A. Knight Kathleen E. Malone Anne S. Reiner Leslie Bernstein Xiaolin Liang Roy E. Shore Marilyn Stovall WECARE Study Collaborative Group Jonine L. Bernstein Body mass index, weight change, and risk of second primary breast cancer in the WECARE study: influence of estrogen receptor status of the first breast cancer Cancer Medicine Body mass index contralateral breast cancer estrogen receptor |
| title | Body mass index, weight change, and risk of second primary breast cancer in the WECARE study: influence of estrogen receptor status of the first breast cancer |
| title_full | Body mass index, weight change, and risk of second primary breast cancer in the WECARE study: influence of estrogen receptor status of the first breast cancer |
| title_fullStr | Body mass index, weight change, and risk of second primary breast cancer in the WECARE study: influence of estrogen receptor status of the first breast cancer |
| title_full_unstemmed | Body mass index, weight change, and risk of second primary breast cancer in the WECARE study: influence of estrogen receptor status of the first breast cancer |
| title_short | Body mass index, weight change, and risk of second primary breast cancer in the WECARE study: influence of estrogen receptor status of the first breast cancer |
| title_sort | body mass index weight change and risk of second primary breast cancer in the wecare study influence of estrogen receptor status of the first breast cancer |
| topic | Body mass index contralateral breast cancer estrogen receptor |
| url | https://doi.org/10.1002/cam4.890 |
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