Differentially expressed non-coding RNAs and their regulatory networks in liver cancer
The vast majority of human transcriptome is represented by various types of small RNAs with little or no protein-coding capability referred to as non-coding RNAs (ncRNAs). Functional ncRNAs include microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), which are expressed...
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| Format: | Article |
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Elsevier
2023-09-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023064319 |
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| author | Nurbubu T. Moldogazieva Sergey P. Zavadskiy Dmitry V. Astakhov Susanna S. Sologova Arus G. Margaryan Anastasiya A. Safrygina Elena A. Smolyarchuk |
| author_facet | Nurbubu T. Moldogazieva Sergey P. Zavadskiy Dmitry V. Astakhov Susanna S. Sologova Arus G. Margaryan Anastasiya A. Safrygina Elena A. Smolyarchuk |
| author_sort | Nurbubu T. Moldogazieva |
| collection | DOAJ |
| description | The vast majority of human transcriptome is represented by various types of small RNAs with little or no protein-coding capability referred to as non-coding RNAs (ncRNAs). Functional ncRNAs include microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), which are expressed at very low, but stable and reproducible levels in a variety of cell types. ncRNAs regulate gene expression due to miRNA capability of complementary base pairing with mRNAs, whereas lncRNAs and circRNAs can sponge miRNAs off their target mRNAs to act as competitive endogenous RNAs (ceRNAs). Each miRNA can target multiple mRNAs and a single mRNA can interact with several miRNAs, thereby creating miRNA-mRNA, lncRNA-miRNA-mRNA, and circRNA-miRNA-mRNA regulatory networks. Over the past few years, a variety of differentially expressed miRNAs, lncRNAs, and circRNAs (DEMs, DELs, and DECs, respectively) have been linked to cancer pathogenesis. They can exert both oncogenic and tumor suppressor roles. In this review, we discuss the recent advancements in uncovering the roles of DEMs, DELs, and DECs and their networks in aberrant cell signaling, cell cycle, transcription, angiogenesis, and apoptosis, as well as tumor microenvironment remodeling and metabolic reprogramming during hepatocarcinogenesis. We highlight the potential and challenges in the use of differentially expressed ncRNAs as biomarkers for liver cancer diagnosis and prognosis. |
| first_indexed | 2024-03-11T20:51:40Z |
| format | Article |
| id | doaj.art-7398d8c7f2ce449e958f9593f87265f8 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-11T20:51:40Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-7398d8c7f2ce449e958f9593f87265f82023-10-01T05:58:53ZengElsevierHeliyon2405-84402023-09-0199e19223Differentially expressed non-coding RNAs and their regulatory networks in liver cancerNurbubu T. Moldogazieva0Sergey P. Zavadskiy1Dmitry V. Astakhov2Susanna S. Sologova3Arus G. Margaryan4Anastasiya A. Safrygina5Elena A. Smolyarchuk6Department of Pharmacology, Nelyubin Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University, 119991, 8 Trubetskaya str., Moscow, Russia; Corresponding author.Department of Pharmacology, Nelyubin Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University, 119991, 8 Trubetskaya str., Moscow, RussiaDepartment of Biochemistry, Institute of Biodesign and Complex Systems Modelling, I.M. Sechenov First Moscow State Medical University, 119991, 8 Trubetskaya str., Moscow, RussiaDepartment of Pharmacology, Nelyubin Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University, 119991, 8 Trubetskaya str., Moscow, RussiaDepartment of Pharmacology, Nelyubin Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University, 119991, 8 Trubetskaya str., Moscow, RussiaDepartment of Pharmacology, Nelyubin Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University, 119991, 8 Trubetskaya str., Moscow, RussiaDepartment of Pharmacology, Nelyubin Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University, 119991, 8 Trubetskaya str., Moscow, RussiaThe vast majority of human transcriptome is represented by various types of small RNAs with little or no protein-coding capability referred to as non-coding RNAs (ncRNAs). Functional ncRNAs include microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), which are expressed at very low, but stable and reproducible levels in a variety of cell types. ncRNAs regulate gene expression due to miRNA capability of complementary base pairing with mRNAs, whereas lncRNAs and circRNAs can sponge miRNAs off their target mRNAs to act as competitive endogenous RNAs (ceRNAs). Each miRNA can target multiple mRNAs and a single mRNA can interact with several miRNAs, thereby creating miRNA-mRNA, lncRNA-miRNA-mRNA, and circRNA-miRNA-mRNA regulatory networks. Over the past few years, a variety of differentially expressed miRNAs, lncRNAs, and circRNAs (DEMs, DELs, and DECs, respectively) have been linked to cancer pathogenesis. They can exert both oncogenic and tumor suppressor roles. In this review, we discuss the recent advancements in uncovering the roles of DEMs, DELs, and DECs and their networks in aberrant cell signaling, cell cycle, transcription, angiogenesis, and apoptosis, as well as tumor microenvironment remodeling and metabolic reprogramming during hepatocarcinogenesis. We highlight the potential and challenges in the use of differentially expressed ncRNAs as biomarkers for liver cancer diagnosis and prognosis.http://www.sciencedirect.com/science/article/pii/S2405844023064319miRNAlncRNAcircRNARegulatory networksHepatocellular carcinomaIntrahepatic cholangiocarcinoma |
| spellingShingle | Nurbubu T. Moldogazieva Sergey P. Zavadskiy Dmitry V. Astakhov Susanna S. Sologova Arus G. Margaryan Anastasiya A. Safrygina Elena A. Smolyarchuk Differentially expressed non-coding RNAs and their regulatory networks in liver cancer Heliyon miRNA lncRNA circRNA Regulatory networks Hepatocellular carcinoma Intrahepatic cholangiocarcinoma |
| title | Differentially expressed non-coding RNAs and their regulatory networks in liver cancer |
| title_full | Differentially expressed non-coding RNAs and their regulatory networks in liver cancer |
| title_fullStr | Differentially expressed non-coding RNAs and their regulatory networks in liver cancer |
| title_full_unstemmed | Differentially expressed non-coding RNAs and their regulatory networks in liver cancer |
| title_short | Differentially expressed non-coding RNAs and their regulatory networks in liver cancer |
| title_sort | differentially expressed non coding rnas and their regulatory networks in liver cancer |
| topic | miRNA lncRNA circRNA Regulatory networks Hepatocellular carcinoma Intrahepatic cholangiocarcinoma |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023064319 |
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