Genotoxicity and Gene Expression in the Rat Lung Tissue following Instillation and Inhalation of Different Variants of Amorphous Silica Nanomaterials (aSiO<sub>2</sub> NM)

Genotoxicity and Gene Expression in the Rat Lung Tissue following Instillation and Inhalation of Different Variants of Amorphous Silica Nanomaterials (aSiO<sub>2</sub> NM)

Several reports on amorphous silica nanomaterial (aSiO<sub>2</sub> NM) toxicity have been questioning their safety. Herein, we investigated the in vivo pulmonary toxicity of four variants of aSiO<sub>2</sub> NM: SiO<sub>2</sub>_15_Unmod, SiO<sub>2</sub>...

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Bibliographic Details
Main Authors: Fátima Brandão, Carla Costa, Maria João Bessa, Elise Dumortier, Florence Debacq-Chainiaux, Roland Hubaux, Michel Salmon, Julie Laloy, Miruna S. Stan, Anca Hermenean, Sami Gharbia, Anca Dinischiotu, Anne Bannuscher, Bryan Hellack, Andrea Haase, Sónia Fraga, João Paulo Teixeira
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Nanomaterials
Subjects:
silica nanomaterials
in vivo inhalation
in vivo instillation
rat lung
DNA damage
gene expression
Online Access:https://www.mdpi.com/2079-4991/11/6/1502

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