Alpha-fetoprotein-producing rectal cancer successfully responded to preoperative chemoradiotherapy: case report
Abstract Background Alpha-fetoprotein (AFP) is produced by some tumors, such as hepatocellular carcinoma and yolk sac tumors, leading to an increase in serum AFP level. However, AFP in colorectal cancer is extremely rare. Treatment for AFP-producing cancer is often performed according to conventiona...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2018-09-01
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| Series: | Surgical Case Reports |
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| Online Access: | http://link.springer.com/article/10.1186/s40792-018-0520-6 |
| _version_ | 1818421890673278976 |
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| author | Yuki Nakamura Kenji Matsuda Shozo Yokoyama Koichi Tamura Yasuyuki Mitani Hiromitsu Iwamoto Yuki Mizumoto Daisuke Murakami Masakazu Fujimoto Hiroki Yamaue |
| author_facet | Yuki Nakamura Kenji Matsuda Shozo Yokoyama Koichi Tamura Yasuyuki Mitani Hiromitsu Iwamoto Yuki Mizumoto Daisuke Murakami Masakazu Fujimoto Hiroki Yamaue |
| author_sort | Yuki Nakamura |
| collection | DOAJ |
| description | Abstract Background Alpha-fetoprotein (AFP) is produced by some tumors, such as hepatocellular carcinoma and yolk sac tumors, leading to an increase in serum AFP level. However, AFP in colorectal cancer is extremely rare. Treatment for AFP-producing cancer is often performed according to conventional methods, but oncological outcomes of both surgery and chemotherapy are poor. We report a case of a patient with AFP-producing rectal cancer which successfully responded to preoperative chemoradiotherapy. Case presentation Rectal tumor was diagnosed in a 68-year-old man referred to our hospital. Colonoscopy showed a type 2 tumor in the lower rectum, and biopsy revealed an adenocarcinoma with enteroblastic differentiation. Serum tumor marker levels were 8.8 ng/ml in carcinoembryonic antigen (CEA) and 28.3 ng/ml in AFP. Clinical diagnosis was stage IIIB (T3N1M0), and preoperative chemoradiotherapy was performed to prevent local recurrence. Effective tumor reduction was observed, and serum tumor marker levels decreased to normal range. Low anterior resection with temporary diverting ileostomy was performed, and histology revealed residual adenocarcinoma. Pathological diagnosis was stage I (T2N0M0). The tumor was found to be an AFP-producing adenocarcinoma on further immunohistopathological examination. The postoperative course was uneventful, and the patient received adjuvant chemotherapy for 3 months. Conclusions The outcomes of preoperative chemoradiotherapy against AFP-producing rectal cancer are reported here for the first time. Based on our experience with this patient, it appears preoperative chemoradiotherapy for patients with AFP-producing advanced rectal cancer is feasible. |
| first_indexed | 2024-12-14T13:17:33Z |
| format | Article |
| id | doaj.art-739cccf02ad84a3fac05d52255cd302c |
| institution | Directory Open Access Journal |
| issn | 2198-7793 |
| language | English |
| last_indexed | 2024-12-14T13:17:33Z |
| publishDate | 2018-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj.art-739cccf02ad84a3fac05d52255cd302c2022-12-21T23:00:01ZengSpringerOpenSurgical Case Reports2198-77932018-09-01411510.1186/s40792-018-0520-6Alpha-fetoprotein-producing rectal cancer successfully responded to preoperative chemoradiotherapy: case reportYuki Nakamura0Kenji Matsuda1Shozo Yokoyama2Koichi Tamura3Yasuyuki Mitani4Hiromitsu Iwamoto5Yuki Mizumoto6Daisuke Murakami7Masakazu Fujimoto8Hiroki Yamaue9Second Department of Surgery, School of Medicine, Wakayama Medical UniversitySecond Department of Surgery, School of Medicine, Wakayama Medical UniversitySecond Department of Surgery, School of Medicine, Wakayama Medical UniversitySecond Department of Surgery, School of Medicine, Wakayama Medical UniversitySecond Department of Surgery, School of Medicine, Wakayama Medical UniversitySecond Department of Surgery, School of Medicine, Wakayama Medical UniversitySecond Department of Surgery, School of Medicine, Wakayama Medical UniversitySecond Department of Surgery, School of Medicine, Wakayama Medical UniversityDepartment of Human Pathology, School of Medicine, Wakayama Medical UniversitySecond Department of Surgery, School of Medicine, Wakayama Medical UniversityAbstract Background Alpha-fetoprotein (AFP) is produced by some tumors, such as hepatocellular carcinoma and yolk sac tumors, leading to an increase in serum AFP level. However, AFP in colorectal cancer is extremely rare. Treatment for AFP-producing cancer is often performed according to conventional methods, but oncological outcomes of both surgery and chemotherapy are poor. We report a case of a patient with AFP-producing rectal cancer which successfully responded to preoperative chemoradiotherapy. Case presentation Rectal tumor was diagnosed in a 68-year-old man referred to our hospital. Colonoscopy showed a type 2 tumor in the lower rectum, and biopsy revealed an adenocarcinoma with enteroblastic differentiation. Serum tumor marker levels were 8.8 ng/ml in carcinoembryonic antigen (CEA) and 28.3 ng/ml in AFP. Clinical diagnosis was stage IIIB (T3N1M0), and preoperative chemoradiotherapy was performed to prevent local recurrence. Effective tumor reduction was observed, and serum tumor marker levels decreased to normal range. Low anterior resection with temporary diverting ileostomy was performed, and histology revealed residual adenocarcinoma. Pathological diagnosis was stage I (T2N0M0). The tumor was found to be an AFP-producing adenocarcinoma on further immunohistopathological examination. The postoperative course was uneventful, and the patient received adjuvant chemotherapy for 3 months. Conclusions The outcomes of preoperative chemoradiotherapy against AFP-producing rectal cancer are reported here for the first time. Based on our experience with this patient, it appears preoperative chemoradiotherapy for patients with AFP-producing advanced rectal cancer is feasible.http://link.springer.com/article/10.1186/s40792-018-0520-6Alpha-fetoprotein (AFP)Rectal cancerChemoradiotherapy |
| spellingShingle | Yuki Nakamura Kenji Matsuda Shozo Yokoyama Koichi Tamura Yasuyuki Mitani Hiromitsu Iwamoto Yuki Mizumoto Daisuke Murakami Masakazu Fujimoto Hiroki Yamaue Alpha-fetoprotein-producing rectal cancer successfully responded to preoperative chemoradiotherapy: case report Surgical Case Reports Alpha-fetoprotein (AFP) Rectal cancer Chemoradiotherapy |
| title | Alpha-fetoprotein-producing rectal cancer successfully responded to preoperative chemoradiotherapy: case report |
| title_full | Alpha-fetoprotein-producing rectal cancer successfully responded to preoperative chemoradiotherapy: case report |
| title_fullStr | Alpha-fetoprotein-producing rectal cancer successfully responded to preoperative chemoradiotherapy: case report |
| title_full_unstemmed | Alpha-fetoprotein-producing rectal cancer successfully responded to preoperative chemoradiotherapy: case report |
| title_short | Alpha-fetoprotein-producing rectal cancer successfully responded to preoperative chemoradiotherapy: case report |
| title_sort | alpha fetoprotein producing rectal cancer successfully responded to preoperative chemoradiotherapy case report |
| topic | Alpha-fetoprotein (AFP) Rectal cancer Chemoradiotherapy |
| url | http://link.springer.com/article/10.1186/s40792-018-0520-6 |
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