Lipoprotein-associated phospholipase A2 (Lp-PLA2) – possible diagnostic and risk biomarker in chronic ischaemic heart disease
In a group of 208 patients with chronic ischaemic heart disease, the variation of A2-associated-LDL phosphatase (Lp-PLA2) serum concentration values was analysed in dynamics at a two-week interval. The conclusion of the study is that the values of serum concentration of Lp-PLA2 can be accepted as a...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-01-01
|
| Series: | Journal of Enzyme Inhibition and Medicinal Chemistry |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/14756366.2020.1839447 |
| _version_ | 1829463769407815680 |
|---|---|
| author | Adriana Diaconu Bogdan-Ioan Coculescu Gheorghe Manole Horațiu Vultur Elena Claudia Coculescu Cristina Maria Stocheci Ioan-Sorin Tudorache Alexandra-Ligia Dincă Valeriu Gabi Dincă |
| author_facet | Adriana Diaconu Bogdan-Ioan Coculescu Gheorghe Manole Horațiu Vultur Elena Claudia Coculescu Cristina Maria Stocheci Ioan-Sorin Tudorache Alexandra-Ligia Dincă Valeriu Gabi Dincă |
| author_sort | Adriana Diaconu |
| collection | DOAJ |
| description | In a group of 208 patients with chronic ischaemic heart disease, the variation of A2-associated-LDL phosphatase (Lp-PLA2) serum concentration values was analysed in dynamics at a two-week interval. The conclusion of the study is that the values of serum concentration of Lp-PLA2 can be accepted as a biomarker with diagnostic specificity for chronic ischaemic heart disease, a parameter of real utility in medical practice, both in situations where the patient, although clinically reporting the existence of angina pectoris, does not show specific changes on an EKG, and for the assessment of the response to personalised therapy. |
| first_indexed | 2024-12-13T13:36:36Z |
| format | Article |
| id | doaj.art-739e169416cc4ced93fe3f74ef20427f |
| institution | Directory Open Access Journal |
| issn | 1475-6366 1475-6374 |
| language | English |
| last_indexed | 2024-12-13T13:36:36Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Enzyme Inhibition and Medicinal Chemistry |
| spelling | doaj.art-739e169416cc4ced93fe3f74ef20427f2022-12-21T23:43:47ZengTaylor & Francis GroupJournal of Enzyme Inhibition and Medicinal Chemistry1475-63661475-63742021-01-01361687310.1080/14756366.2020.18394471839447Lipoprotein-associated phospholipase A2 (Lp-PLA2) – possible diagnostic and risk biomarker in chronic ischaemic heart diseaseAdriana Diaconu0Bogdan-Ioan Coculescu1Gheorghe Manole2Horațiu Vultur3Elena Claudia Coculescu4Cristina Maria Stocheci5Ioan-Sorin Tudorache6Alexandra-Ligia Dincă7Valeriu Gabi Dincă8Faculty of Medicine, Carol Davila University of Medicine and PharmacyFaculty of Medicine, Titu Maiorescu UniversityColentina Clinical HospitalFaculty of Medicine, Carol Davila University of Medicine and PharmacyFaculty of Dental Medicine, Carol Davila University of Medicine and PharmacyFaculty of Sciences, University of PitestiFaculty of Medicine, Titu Maiorescu UniversityMedicover HospitalFaculty of Medicine, Titu Maiorescu UniversityIn a group of 208 patients with chronic ischaemic heart disease, the variation of A2-associated-LDL phosphatase (Lp-PLA2) serum concentration values was analysed in dynamics at a two-week interval. The conclusion of the study is that the values of serum concentration of Lp-PLA2 can be accepted as a biomarker with diagnostic specificity for chronic ischaemic heart disease, a parameter of real utility in medical practice, both in situations where the patient, although clinically reporting the existence of angina pectoris, does not show specific changes on an EKG, and for the assessment of the response to personalised therapy.http://dx.doi.org/10.1080/14756366.2020.1839447a2 phospholipase (pla2); arachidonic acid (aa); chronic ischaemic heart disease; oxidative stressbiomarker |
| spellingShingle | Adriana Diaconu Bogdan-Ioan Coculescu Gheorghe Manole Horațiu Vultur Elena Claudia Coculescu Cristina Maria Stocheci Ioan-Sorin Tudorache Alexandra-Ligia Dincă Valeriu Gabi Dincă Lipoprotein-associated phospholipase A2 (Lp-PLA2) – possible diagnostic and risk biomarker in chronic ischaemic heart disease Journal of Enzyme Inhibition and Medicinal Chemistry a2 phospholipase (pla2); arachidonic acid (aa); chronic ischaemic heart disease; oxidative stress biomarker |
| title | Lipoprotein-associated phospholipase A2 (Lp-PLA2) – possible diagnostic and risk biomarker in chronic ischaemic heart disease |
| title_full | Lipoprotein-associated phospholipase A2 (Lp-PLA2) – possible diagnostic and risk biomarker in chronic ischaemic heart disease |
| title_fullStr | Lipoprotein-associated phospholipase A2 (Lp-PLA2) – possible diagnostic and risk biomarker in chronic ischaemic heart disease |
| title_full_unstemmed | Lipoprotein-associated phospholipase A2 (Lp-PLA2) – possible diagnostic and risk biomarker in chronic ischaemic heart disease |
| title_short | Lipoprotein-associated phospholipase A2 (Lp-PLA2) – possible diagnostic and risk biomarker in chronic ischaemic heart disease |
| title_sort | lipoprotein associated phospholipase a2 lp pla2 possible diagnostic and risk biomarker in chronic ischaemic heart disease |
| topic | a2 phospholipase (pla2); arachidonic acid (aa); chronic ischaemic heart disease; oxidative stress biomarker |
| url | http://dx.doi.org/10.1080/14756366.2020.1839447 |
| work_keys_str_mv | AT adrianadiaconu lipoproteinassociatedphospholipasea2lppla2possiblediagnosticandriskbiomarkerinchronicischaemicheartdisease AT bogdanioancoculescu lipoproteinassociatedphospholipasea2lppla2possiblediagnosticandriskbiomarkerinchronicischaemicheartdisease AT gheorghemanole lipoproteinassociatedphospholipasea2lppla2possiblediagnosticandriskbiomarkerinchronicischaemicheartdisease AT horatiuvultur lipoproteinassociatedphospholipasea2lppla2possiblediagnosticandriskbiomarkerinchronicischaemicheartdisease AT elenaclaudiacoculescu lipoproteinassociatedphospholipasea2lppla2possiblediagnosticandriskbiomarkerinchronicischaemicheartdisease AT cristinamariastocheci lipoproteinassociatedphospholipasea2lppla2possiblediagnosticandriskbiomarkerinchronicischaemicheartdisease AT ioansorintudorache lipoproteinassociatedphospholipasea2lppla2possiblediagnosticandriskbiomarkerinchronicischaemicheartdisease AT alexandraligiadinca lipoproteinassociatedphospholipasea2lppla2possiblediagnosticandriskbiomarkerinchronicischaemicheartdisease AT valeriugabidinca lipoproteinassociatedphospholipasea2lppla2possiblediagnosticandriskbiomarkerinchronicischaemicheartdisease |