Matrix Selection for the Visualization of Small Molecules and Lipids in Brain Tumors Using Untargeted MALDI-TOF Mass Spectrometry Imaging

Matrix Selection for the Visualization of Small Molecules and Lipids in Brain Tumors Using Untargeted MALDI-TOF Mass Spectrometry Imaging

Matrix-assisted laser desorption/ionization mass spectrometry imaging allows for the study of metabolic activity in the tumor microenvironment of brain cancers. The detectable metabolites within these tumors are contingent upon the choice of matrix, deposition technique, and polarity setting. In thi...

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Bibliographic Details
Main Authors: Tianyao Lu, Lutz Freytag, Vinod K. Narayana, Zachery Moore, Shannon J. Oliver, Adam Valkovic, Brunda Nijagal, Amanda L. Peterson, David P. de Souza, Malcolm J. McConville, James R. Whittle, Sarah A. Best, Saskia Freytag
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Metabolites
Subjects:
MALDI-TOF
atmospheric pressure
matrix selection
brain cancer
glioma
Online Access:https://www.mdpi.com/2218-1989/13/11/1139

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