Microfluidic Devices for Terahertz Spectroscopy of Live Cells Toward Lab-on-a-Chip Applications
THz spectroscopy is an emerging technique for studying the dynamics and interactions of cells and biomolecules, but many practical challenges still remain in experimental studies. We present a prototype of simple and inexpensive cell-trapping microfluidic chip for THz spectroscopic study of live cel...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-04-01
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| Series: | Sensors |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1424-8220/16/4/476 |
| _version_ | 1811298790934577152 |
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| author | Qi Tang Min Liang Yi Lu Pak Kin Wong Gerald J. Wilmink Donna Zhang Hao Xin |
| author_facet | Qi Tang Min Liang Yi Lu Pak Kin Wong Gerald J. Wilmink Donna Zhang Hao Xin |
| author_sort | Qi Tang |
| collection | DOAJ |
| description | THz spectroscopy is an emerging technique for studying the dynamics and interactions of cells and biomolecules, but many practical challenges still remain in experimental studies. We present a prototype of simple and inexpensive cell-trapping microfluidic chip for THz spectroscopic study of live cells. Cells are transported, trapped and concentrated into the THz exposure region by applying an AC bias signal while the chip maintains a steady temperature at 37 °C by resistive heating. We conduct some preliminary experiments on E. coli and T-cell solution and compare the transmission spectra of empty channels, channels filled with aqueous media only, and channels filled with aqueous media with un-concentrated and concentrated cells. |
| first_indexed | 2024-04-13T06:24:44Z |
| format | Article |
| id | doaj.art-73a676dc620f42539ae6b4c08606c630 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-13T06:24:44Z |
| publishDate | 2016-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-73a676dc620f42539ae6b4c08606c6302022-12-22T02:58:28ZengMDPI AGSensors1424-82202016-04-0116447610.3390/s16040476s16040476Microfluidic Devices for Terahertz Spectroscopy of Live Cells Toward Lab-on-a-Chip ApplicationsQi Tang0Min Liang1Yi Lu2Pak Kin Wong3Gerald J. Wilmink4Donna Zhang5Hao Xin6Department of Electrical and Computer Engineering, University of Arizona, Tucson, AZ 85721, USADepartment of Electrical and Computer Engineering, University of Arizona, Tucson, AZ 85721, USADepartment of Biomedical Engineering, Pennsylvania State University, University Park, PA 16802, USADepartment of Biomedical Engineering, Pennsylvania State University, University Park, PA 16802, USAWiseWear Corporation, New York, NY 10018, USACollege of Pharmacy, University of Arizona, Tucson, AZ 85721, USADepartment of Electrical and Computer Engineering, University of Arizona, Tucson, AZ 85721, USATHz spectroscopy is an emerging technique for studying the dynamics and interactions of cells and biomolecules, but many practical challenges still remain in experimental studies. We present a prototype of simple and inexpensive cell-trapping microfluidic chip for THz spectroscopic study of live cells. Cells are transported, trapped and concentrated into the THz exposure region by applying an AC bias signal while the chip maintains a steady temperature at 37 °C by resistive heating. We conduct some preliminary experiments on E. coli and T-cell solution and compare the transmission spectra of empty channels, channels filled with aqueous media only, and channels filled with aqueous media with un-concentrated and concentrated cells.http://www.mdpi.com/1424-8220/16/4/476cell trappinglab-on-a-chipmicrofluidicsTHz spectroscopy |
| spellingShingle | Qi Tang Min Liang Yi Lu Pak Kin Wong Gerald J. Wilmink Donna Zhang Hao Xin Microfluidic Devices for Terahertz Spectroscopy of Live Cells Toward Lab-on-a-Chip Applications Sensors cell trapping lab-on-a-chip microfluidics THz spectroscopy |
| title | Microfluidic Devices for Terahertz Spectroscopy of Live Cells Toward Lab-on-a-Chip Applications |
| title_full | Microfluidic Devices for Terahertz Spectroscopy of Live Cells Toward Lab-on-a-Chip Applications |
| title_fullStr | Microfluidic Devices for Terahertz Spectroscopy of Live Cells Toward Lab-on-a-Chip Applications |
| title_full_unstemmed | Microfluidic Devices for Terahertz Spectroscopy of Live Cells Toward Lab-on-a-Chip Applications |
| title_short | Microfluidic Devices for Terahertz Spectroscopy of Live Cells Toward Lab-on-a-Chip Applications |
| title_sort | microfluidic devices for terahertz spectroscopy of live cells toward lab on a chip applications |
| topic | cell trapping lab-on-a-chip microfluidics THz spectroscopy |
| url | http://www.mdpi.com/1424-8220/16/4/476 |
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