“Pulsed Hypoxia” Gradually Reprograms Breast Cancer Fibroblasts into Pro-Tumorigenic Cells via Mesenchymal–Epithelial Transition

“Pulsed Hypoxia” Gradually Reprograms Breast Cancer Fibroblasts into Pro-Tumorigenic Cells via Mesenchymal–Epithelial Transition

Hypoxia arises in most growing solid tumors and can lead to pleotropic effects that potentially increase tumor aggressiveness and resistance to therapy through regulation of the expression of genes associated with the epithelial–mesenchymal transition (EMT) and mesenchymal–epithelial transition (MET...

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Bibliographic Details
Main Authors: Anna Nushtaeva, Mikhail Ermakov, Maria Abdurakhmanova, Olga Troitskaya, Tatyana Belovezhets, Mikhail Varlamov, Tatyana Gayner, Vladimir Richter, Olga Koval
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
hypoxia
cancer associated fibroblasts
pro-tumorigenic cells
c-MYC
OVOL2
mesenchymal to epithelial transition
Online Access:https://www.mdpi.com/1422-0067/24/3/2494

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