BAK regulates catalase release from peroxisomes
Loss of voltage-dependent anion channel 2 (VDAC2) leads to impaired peroxisome biogenesis in mammalian cells. Knockdown of BAK restores peroxisomal biogenesis in VDAC2-deficient cells, where BAK localization shifts from mitochondria to peroxisomes. Moreover, overexpression of BAK activators in wild-...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2017-05-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2017.1306610 |
| _version_ | 1797677216220315648 |
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| author | Yukio Fujiki Non Miyata Satoru Mukai Kanji Okumoto Emily H. Cheng |
| author_facet | Yukio Fujiki Non Miyata Satoru Mukai Kanji Okumoto Emily H. Cheng |
| author_sort | Yukio Fujiki |
| collection | DOAJ |
| description | Loss of voltage-dependent anion channel 2 (VDAC2) leads to impaired peroxisome biogenesis in mammalian cells. Knockdown of BAK restores peroxisomal biogenesis in VDAC2-deficient cells, where BAK localization shifts from mitochondria to peroxisomes. Moreover, overexpression of BAK activators in wild-type cells permeabilizes peroxisomes in a BAK-dependent manner. Together, BAK most likely regulates peroxisomal membrane permeability. |
| first_indexed | 2024-03-11T22:40:45Z |
| format | Article |
| id | doaj.art-73a83b6a004f4936b81ea35719adc20e |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:45Z |
| publishDate | 2017-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-73a83b6a004f4936b81ea35719adc20e2023-09-22T09:10:58ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562017-05-014310.1080/23723556.2017.13066101306610BAK regulates catalase release from peroxisomesYukio Fujiki0Non Miyata1Satoru Mukai2Kanji Okumoto3Emily H. Cheng4Kyushu UniversityKyushu UniversityKyushu UniversityKyushu UniversityMemorial Sloan-Kettering Cancer CenterLoss of voltage-dependent anion channel 2 (VDAC2) leads to impaired peroxisome biogenesis in mammalian cells. Knockdown of BAK restores peroxisomal biogenesis in VDAC2-deficient cells, where BAK localization shifts from mitochondria to peroxisomes. Moreover, overexpression of BAK activators in wild-type cells permeabilizes peroxisomes in a BAK-dependent manner. Together, BAK most likely regulates peroxisomal membrane permeability.http://dx.doi.org/10.1080/23723556.2017.1306610apoptosisbakcatalasecho mutantmembrane permeabilizationoligomerizationoxidative stressperoxisomereactive oxygen speciesvdac2 |
| spellingShingle | Yukio Fujiki Non Miyata Satoru Mukai Kanji Okumoto Emily H. Cheng BAK regulates catalase release from peroxisomes Molecular & Cellular Oncology apoptosis bak catalase cho mutant membrane permeabilization oligomerization oxidative stress peroxisome reactive oxygen species vdac2 |
| title | BAK regulates catalase release from peroxisomes |
| title_full | BAK regulates catalase release from peroxisomes |
| title_fullStr | BAK regulates catalase release from peroxisomes |
| title_full_unstemmed | BAK regulates catalase release from peroxisomes |
| title_short | BAK regulates catalase release from peroxisomes |
| title_sort | bak regulates catalase release from peroxisomes |
| topic | apoptosis bak catalase cho mutant membrane permeabilization oligomerization oxidative stress peroxisome reactive oxygen species vdac2 |
| url | http://dx.doi.org/10.1080/23723556.2017.1306610 |
| work_keys_str_mv | AT yukiofujiki bakregulatescatalasereleasefromperoxisomes AT nonmiyata bakregulatescatalasereleasefromperoxisomes AT satorumukai bakregulatescatalasereleasefromperoxisomes AT kanjiokumoto bakregulatescatalasereleasefromperoxisomes AT emilyhcheng bakregulatescatalasereleasefromperoxisomes |