Role of genetic polymorphism in the development of sepsis in infants
Sepsis and its consequences continue to be a major cause of morbidity and mortality in the intensive care unit (ICU). The evidence that endogenous mediators actually mediate an individual response to the infection has led to the development of different approaches to assess the impact of each person...
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| Format: | Article |
| Language: | English |
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Meshalkin National Medical Research Center
2015-10-01
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| Series: | Патология кровообращения и кардиохирургия |
| Subjects: | |
| Online Access: | http://journalmeshalkin.ru/index.php/heartjournal/article/view/99 |
| _version_ | 1797709477534760960 |
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| author | С. А. Сергеев О. В. Струнин Е. Е. Литасова |
| author_facet | С. А. Сергеев О. В. Струнин Е. Е. Литасова |
| author_sort | С. А. Сергеев |
| collection | DOAJ |
| description | Sepsis and its consequences continue to be a major cause of morbidity and mortality in the intensive care unit (ICU). The evidence that endogenous mediators actually mediate an individual response to the infection has led to the development of different approaches to assess the impact of each person on the course of the disease. The role of the genetic background and the susceptibility to human inflammatory response amplitude are determined by the variability of the genes encoding endogenous mediators which are produced during inflammation. Pro-and anti-inflammatory reactions influence the susceptibility and the outcomes in patients with sepsis and systemic inflammation. Thus, all genes encoding proteins involved in the transduction of inflammatory genes are candidates for detection of a human's genetic background responsible for the difference in interpersonal systemic inflammatory reaction. |
| first_indexed | 2024-03-12T06:37:08Z |
| format | Article |
| id | doaj.art-73a9312474524c868bd25260e408f48a |
| institution | Directory Open Access Journal |
| issn | 1681-3472 2500-3119 |
| language | English |
| last_indexed | 2024-03-12T06:37:08Z |
| publishDate | 2015-10-01 |
| publisher | Meshalkin National Medical Research Center |
| record_format | Article |
| series | Патология кровообращения и кардиохирургия |
| spelling | doaj.art-73a9312474524c868bd25260e408f48a2023-09-03T01:14:29ZengMeshalkin National Medical Research CenterПатология кровообращения и кардиохирургия1681-34722500-31192015-10-01174596210.21688/1681-3472-2013-4-59-62819Role of genetic polymorphism in the development of sepsis in infantsС. А. Сергеев0О. В. Струнин1Е. Е. Литасова2ФГБУ «ННИИПК им. акад. Е.Н. Мешалкина» Минздрава РоссииФГБУ «ННИИПК им. акад. Е.Н. Мешалкина» Минздрава РоссииФГБУ «ННИИПК им. акад. Е.Н. Мешалкина» Минздрава РоссииSepsis and its consequences continue to be a major cause of morbidity and mortality in the intensive care unit (ICU). The evidence that endogenous mediators actually mediate an individual response to the infection has led to the development of different approaches to assess the impact of each person on the course of the disease. The role of the genetic background and the susceptibility to human inflammatory response amplitude are determined by the variability of the genes encoding endogenous mediators which are produced during inflammation. Pro-and anti-inflammatory reactions influence the susceptibility and the outcomes in patients with sepsis and systemic inflammation. Thus, all genes encoding proteins involved in the transduction of inflammatory genes are candidates for detection of a human's genetic background responsible for the difference in interpersonal systemic inflammatory reaction.http://journalmeshalkin.ru/index.php/heartjournal/article/view/99СЕПСИСПОЛИМОРФИЗМГЕНЕТИЧЕСКАЯ ПРЕДРАСПОЛОЖЕННОСТЬГЕНЕТИЧЕСКАЯ ИЗМЕНЧИВОСТЬГЕН |
| spellingShingle | С. А. Сергеев О. В. Струнин Е. Е. Литасова Role of genetic polymorphism in the development of sepsis in infants Патология кровообращения и кардиохирургия СЕПСИС ПОЛИМОРФИЗМ ГЕНЕТИЧЕСКАЯ ПРЕДРАСПОЛОЖЕННОСТЬ ГЕНЕТИЧЕСКАЯ ИЗМЕНЧИВОСТЬ ГЕН |
| title | Role of genetic polymorphism in the development of sepsis in infants |
| title_full | Role of genetic polymorphism in the development of sepsis in infants |
| title_fullStr | Role of genetic polymorphism in the development of sepsis in infants |
| title_full_unstemmed | Role of genetic polymorphism in the development of sepsis in infants |
| title_short | Role of genetic polymorphism in the development of sepsis in infants |
| title_sort | role of genetic polymorphism in the development of sepsis in infants |
| topic | СЕПСИС ПОЛИМОРФИЗМ ГЕНЕТИЧЕСКАЯ ПРЕДРАСПОЛОЖЕННОСТЬ ГЕНЕТИЧЕСКАЯ ИЗМЕНЧИВОСТЬ ГЕН |
| url | http://journalmeshalkin.ru/index.php/heartjournal/article/view/99 |
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