Retinal vessel diameter changes induced by transient high perfusion pressure
<b>AIM:</b> To investigate the effects of transient high perfusion pressure on the retinal vessel diameter and retinal ganglion cells. <b>METHODS:</b> The animals were divided into four groups according to different infusion pressure and infusion time (60 mm Hg-3m...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2014-08-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://www.ijo.cn/en_publish/2014/4/20140403.pdf |
| _version_ | 1811293084424601600 |
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| author | Yin-Ying Zhao Ping-Jun Chang Fang Yu Yun-E Zhao |
| author_facet | Yin-Ying Zhao Ping-Jun Chang Fang Yu Yun-E Zhao |
| author_sort | Yin-Ying Zhao |
| collection | DOAJ |
| description | <b>AIM:</b> To investigate the effects of transient high perfusion pressure on the retinal vessel diameter and retinal ganglion cells.
<b>METHODS:</b> The animals were divided into four groups according to different infusion pressure and infusion time (60 mm Hg-3min, 60 mm Hg-5min, 100 mm Hg-3min, 100 mm Hg-5min). Each group consisted of six rabbits. The left eye was used as the experimental eye and the right as a control. Retinal vascular diameters were evaluated before, during infusion, immediately after infusion, 5min, 10min and 30min after infusion based on the fundus photographs. Blood pressure was monitored during infusion. The eyes were removed after 24h. Damage to retinal ganglion cell (RGC) was analyzed by histology.
<b>RESULTS:</b>Retina became whiten and papilla optic was pale during perfusion. Measurements showed significant decrease in retinal artery and vein diameter during perfusion in all of the four groups at the proximal of the edge of the optic disc. The changes were significant in the 100 mm Hg-3min group and 100 mm Hg-5min group compared with 60 mm Hg-3min group (<i>P</i>1<i>=</i>0.025, <i>P</i>2=0.000). The diameters in all the groups recovered completely after 30min of reperfusion. The number of RGC showed no significant changes at the IOP in 100 mm Hg with 5min compared with contralateral untreated eye (<i>P</i>＞0.05).
<b>CONCLUSION:</b> Transient fluctuations during infusion lead to temporal changes of retinal vessels, which could affect the retinal blood circulation. The RGCs were not affected by this transient fluctuation. Further studies are necessary to evaluate the effect of pressure during real-time phacoemusification on retinal blood circulation. |
| first_indexed | 2024-04-13T04:55:19Z |
| format | Article |
| id | doaj.art-73ae91a8e36c4298bcec1d979d9e83f0 |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-04-13T04:55:19Z |
| publishDate | 2014-08-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-73ae91a8e36c4298bcec1d979d9e83f02022-12-22T03:01:30ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982014-08-017460260710.3980/j.issn.2222-3959.2014.04.03Retinal vessel diameter changes induced by transient high perfusion pressureYin-Ying Zhao0Ping-Jun Chang1Fang Yu2Yun-E Zhao3School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China<br>;Affiliated Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, ChinaSchool of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China<br>;Affiliated Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, ChinaSchool of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China<br>;Affiliated Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, ChinaSchool of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China<br>;Affiliated Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China<b>AIM:</b> To investigate the effects of transient high perfusion pressure on the retinal vessel diameter and retinal ganglion cells. <b>METHODS:</b> The animals were divided into four groups according to different infusion pressure and infusion time (60 mm Hg-3min, 60 mm Hg-5min, 100 mm Hg-3min, 100 mm Hg-5min). Each group consisted of six rabbits. The left eye was used as the experimental eye and the right as a control. Retinal vascular diameters were evaluated before, during infusion, immediately after infusion, 5min, 10min and 30min after infusion based on the fundus photographs. Blood pressure was monitored during infusion. The eyes were removed after 24h. Damage to retinal ganglion cell (RGC) was analyzed by histology. <b>RESULTS:</b>Retina became whiten and papilla optic was pale during perfusion. Measurements showed significant decrease in retinal artery and vein diameter during perfusion in all of the four groups at the proximal of the edge of the optic disc. The changes were significant in the 100 mm Hg-3min group and 100 mm Hg-5min group compared with 60 mm Hg-3min group (<i>P</i>1<i>=</i>0.025, <i>P</i>2=0.000). The diameters in all the groups recovered completely after 30min of reperfusion. The number of RGC showed no significant changes at the IOP in 100 mm Hg with 5min compared with contralateral untreated eye (<i>P</i>＞0.05). <b>CONCLUSION:</b> Transient fluctuations during infusion lead to temporal changes of retinal vessels, which could affect the retinal blood circulation. The RGCs were not affected by this transient fluctuation. Further studies are necessary to evaluate the effect of pressure during real-time phacoemusification on retinal blood circulation.http://www.ijo.cn/en_publish/2014/4/20140403.pdfocular perfusion pressureretinal ischemiaretinal ganglion cellsanimalsanimals |
| spellingShingle | Yin-Ying Zhao Ping-Jun Chang Fang Yu Yun-E Zhao Retinal vessel diameter changes induced by transient high perfusion pressure International Journal of Ophthalmology ocular perfusion pressure retinal ischemia retinal ganglion cells animals animals |
| title | Retinal vessel diameter changes induced by transient high perfusion pressure |
| title_full | Retinal vessel diameter changes induced by transient high perfusion pressure |
| title_fullStr | Retinal vessel diameter changes induced by transient high perfusion pressure |
| title_full_unstemmed | Retinal vessel diameter changes induced by transient high perfusion pressure |
| title_short | Retinal vessel diameter changes induced by transient high perfusion pressure |
| title_sort | retinal vessel diameter changes induced by transient high perfusion pressure |
| topic | ocular perfusion pressure retinal ischemia retinal ganglion cells animals animals |
| url | http://www.ijo.cn/en_publish/2014/4/20140403.pdf |
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