Magnitude and determinants of nonadherence and nonreadiness to highly active antiretroviral therapy among people living with HIV/AIDS in Northwest Ethiopia: a cross - sectional study
<p>Abstract</p> <p>Background</p> <p>Adequate antiretroviral drug potency is essential for obtaining therapeutic benefit, however, the behavioral aspects of proper adherence and readiness to medication, often determine therapeutic outcome. Therefore, this study aimed to...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-01-01
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| Series: | AIDS Research and Therapy |
| Online Access: | http://www.aidsrestherapy.com/content/7/1/2 |
| _version_ | 1811298482501189632 |
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| author | Mulu Andargachew Biadglegne Fantahun Tessema Belay Getachew Assefa Emmrich Frank Sack Ulrich |
| author_facet | Mulu Andargachew Biadglegne Fantahun Tessema Belay Getachew Assefa Emmrich Frank Sack Ulrich |
| author_sort | Mulu Andargachew |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Adequate antiretroviral drug potency is essential for obtaining therapeutic benefit, however, the behavioral aspects of proper adherence and readiness to medication, often determine therapeutic outcome. Therefore, this study aimed to assess the level and determinants of nonadherence and nonreadiness to highly active antiretroviral therapy (HAART) among people living with HIV/AIDS (PLWHA) at Gondar University Teaching Hospital and Felege Hiwot Hospital in Northwest Ethiopia.</p> <p>Methods</p> <p>A cross-sectional study was conducted between July and September 2008 using structured interviewer-administered questionnaire. All consecutive adult outpatients who were receiving antiretroviral treatment for at least three months, seen at both hospitals during the study period and able to give informed consent were included in the study. Multivariate logistic regression was used to determine factors associated with nonadherence and nonreadiness.</p> <p>Results</p> <p>A total of 504 study subjects were included in this study. The prevalence rates of nonadherence and nonreadiness to HAART were 87 (17.3%) and 70 (13.9%) respectively. Multivariate logistic regression analysis revealed that medication adverse effects, nonreadiness to HAART, contact with psychiatric care service and having no goal had statistically significant association with nonadherence. Moreover, unwillingness to disclose HIV status was significantly associated with nonreadiness to HAART.</p> <p>Conclusions</p> <p>In this study the level of nonadherence and nonreadiness to HAART seems to be encouraging. Several factors associated with nonadherance and nonreadiness to HAART were identified. Efforts to minimize nonadherence and nonreadiness to HAART should be integrated in to regular clinical follow up of patients.</p> |
| first_indexed | 2024-04-13T06:20:03Z |
| format | Article |
| id | doaj.art-73aed86833e14f18b75341f4aedf1863 |
| institution | Directory Open Access Journal |
| issn | 1742-6405 |
| language | English |
| last_indexed | 2024-04-13T06:20:03Z |
| publishDate | 2010-01-01 |
| publisher | BMC |
| record_format | Article |
| series | AIDS Research and Therapy |
| spelling | doaj.art-73aed86833e14f18b75341f4aedf18632022-12-22T02:58:41ZengBMCAIDS Research and Therapy1742-64052010-01-0171210.1186/1742-6405-7-2Magnitude and determinants of nonadherence and nonreadiness to highly active antiretroviral therapy among people living with HIV/AIDS in Northwest Ethiopia: a cross - sectional studyMulu AndargachewBiadglegne FantahunTessema BelayGetachew AssefaEmmrich FrankSack Ulrich<p>Abstract</p> <p>Background</p> <p>Adequate antiretroviral drug potency is essential for obtaining therapeutic benefit, however, the behavioral aspects of proper adherence and readiness to medication, often determine therapeutic outcome. Therefore, this study aimed to assess the level and determinants of nonadherence and nonreadiness to highly active antiretroviral therapy (HAART) among people living with HIV/AIDS (PLWHA) at Gondar University Teaching Hospital and Felege Hiwot Hospital in Northwest Ethiopia.</p> <p>Methods</p> <p>A cross-sectional study was conducted between July and September 2008 using structured interviewer-administered questionnaire. All consecutive adult outpatients who were receiving antiretroviral treatment for at least three months, seen at both hospitals during the study period and able to give informed consent were included in the study. Multivariate logistic regression was used to determine factors associated with nonadherence and nonreadiness.</p> <p>Results</p> <p>A total of 504 study subjects were included in this study. The prevalence rates of nonadherence and nonreadiness to HAART were 87 (17.3%) and 70 (13.9%) respectively. Multivariate logistic regression analysis revealed that medication adverse effects, nonreadiness to HAART, contact with psychiatric care service and having no goal had statistically significant association with nonadherence. Moreover, unwillingness to disclose HIV status was significantly associated with nonreadiness to HAART.</p> <p>Conclusions</p> <p>In this study the level of nonadherence and nonreadiness to HAART seems to be encouraging. Several factors associated with nonadherance and nonreadiness to HAART were identified. Efforts to minimize nonadherence and nonreadiness to HAART should be integrated in to regular clinical follow up of patients.</p>http://www.aidsrestherapy.com/content/7/1/2 |
| spellingShingle | Mulu Andargachew Biadglegne Fantahun Tessema Belay Getachew Assefa Emmrich Frank Sack Ulrich Magnitude and determinants of nonadherence and nonreadiness to highly active antiretroviral therapy among people living with HIV/AIDS in Northwest Ethiopia: a cross - sectional study AIDS Research and Therapy |
| title | Magnitude and determinants of nonadherence and nonreadiness to highly active antiretroviral therapy among people living with HIV/AIDS in Northwest Ethiopia: a cross - sectional study |
| title_full | Magnitude and determinants of nonadherence and nonreadiness to highly active antiretroviral therapy among people living with HIV/AIDS in Northwest Ethiopia: a cross - sectional study |
| title_fullStr | Magnitude and determinants of nonadherence and nonreadiness to highly active antiretroviral therapy among people living with HIV/AIDS in Northwest Ethiopia: a cross - sectional study |
| title_full_unstemmed | Magnitude and determinants of nonadherence and nonreadiness to highly active antiretroviral therapy among people living with HIV/AIDS in Northwest Ethiopia: a cross - sectional study |
| title_short | Magnitude and determinants of nonadherence and nonreadiness to highly active antiretroviral therapy among people living with HIV/AIDS in Northwest Ethiopia: a cross - sectional study |
| title_sort | magnitude and determinants of nonadherence and nonreadiness to highly active antiretroviral therapy among people living with hiv aids in northwest ethiopia a cross sectional study |
| url | http://www.aidsrestherapy.com/content/7/1/2 |
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