Characterization and Modeling of Reversible Antibody Self-Association Provide Insights into Behavior, Prediction, and Correction

Characterization and Modeling of Reversible Antibody Self-Association Provide Insights into Behavior, Prediction, and Correction

Reversible antibody self-association, while having major developability and therapeutic implications, is not fully understood or readily predictable and correctable. For a strongly self-associating humanized mAb variant, resulting in unacceptable viscosity, the monovalent affinity of self-interactio...

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Bibliographic Details
Main Authors: Carl Mieczkowski, Alan Cheng, Thierry Fischmann, Mark Hsieh, Jeanne Baker, Makiko Uchida, Gopalan Raghunathan, Corey Strickland, Laurence Fayadat-Dilman
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Antibodies
Subjects:
antibody
protein
self-association
self-interaction
developability
in silico prediction
Online Access:https://www.mdpi.com/2073-4468/10/1/8

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