Highly metastatic claudin-low mammary cancers can originate from luminal epithelial cells
The cellular origin and oncogenic drivers promoting claudin-low breast cancer are undefined. Here, the authors report that the consistent activation of oncogenic RAS signaling, as well as regulators of EMT, play a crucial role in the cellular plasticity and maintenance of the mesenchymal and stem ce...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-23957-5 |
| _version_ | 1819122470057148416 |
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| author | Patrick D. Rädler Barbara L. Wehde Aleata A. Triplett Hridaya Shrestha Jonathan H. Shepherd Adam D. Pfefferle Hallgeir Rui Robert D. Cardiff Charles M. Perou Kay-Uwe Wagner |
| author_facet | Patrick D. Rädler Barbara L. Wehde Aleata A. Triplett Hridaya Shrestha Jonathan H. Shepherd Adam D. Pfefferle Hallgeir Rui Robert D. Cardiff Charles M. Perou Kay-Uwe Wagner |
| author_sort | Patrick D. Rädler |
| collection | DOAJ |
| description | The cellular origin and oncogenic drivers promoting claudin-low breast cancer are undefined. Here, the authors report that the consistent activation of oncogenic RAS signaling, as well as regulators of EMT, play a crucial role in the cellular plasticity and maintenance of the mesenchymal and stem cell characteristics of claudin-low mammary cancer cells. |
| first_indexed | 2024-12-22T06:52:58Z |
| format | Article |
| id | doaj.art-73b3b931199c4ef2944a84166e09403e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T06:52:58Z |
| publishDate | 2021-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-73b3b931199c4ef2944a84166e09403e2022-12-21T18:35:05ZengNature PortfolioNature Communications2041-17232021-06-0112111610.1038/s41467-021-23957-5Highly metastatic claudin-low mammary cancers can originate from luminal epithelial cellsPatrick D. Rädler0Barbara L. Wehde1Aleata A. Triplett2Hridaya Shrestha3Jonathan H. Shepherd4Adam D. Pfefferle5Hallgeir Rui6Robert D. Cardiff7Charles M. Perou8Kay-Uwe Wagner9Department of Oncology, Wayne State University School of Medicine and Tumor Biology Program, Barbara Ann Karmanos Cancer InstituteEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical CenterEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical CenterDepartment of Oncology, Wayne State University School of Medicine and Tumor Biology Program, Barbara Ann Karmanos Cancer InstituteDepartment of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel HillDepartment of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel HillDepartment of Pathology, Medical College of WisconsinCenter of Comparative Medicine, University of CaliforniaDepartment of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel HillDepartment of Oncology, Wayne State University School of Medicine and Tumor Biology Program, Barbara Ann Karmanos Cancer InstituteThe cellular origin and oncogenic drivers promoting claudin-low breast cancer are undefined. Here, the authors report that the consistent activation of oncogenic RAS signaling, as well as regulators of EMT, play a crucial role in the cellular plasticity and maintenance of the mesenchymal and stem cell characteristics of claudin-low mammary cancer cells.https://doi.org/10.1038/s41467-021-23957-5 |
| spellingShingle | Patrick D. Rädler Barbara L. Wehde Aleata A. Triplett Hridaya Shrestha Jonathan H. Shepherd Adam D. Pfefferle Hallgeir Rui Robert D. Cardiff Charles M. Perou Kay-Uwe Wagner Highly metastatic claudin-low mammary cancers can originate from luminal epithelial cells Nature Communications |
| title | Highly metastatic claudin-low mammary cancers can originate from luminal epithelial cells |
| title_full | Highly metastatic claudin-low mammary cancers can originate from luminal epithelial cells |
| title_fullStr | Highly metastatic claudin-low mammary cancers can originate from luminal epithelial cells |
| title_full_unstemmed | Highly metastatic claudin-low mammary cancers can originate from luminal epithelial cells |
| title_short | Highly metastatic claudin-low mammary cancers can originate from luminal epithelial cells |
| title_sort | highly metastatic claudin low mammary cancers can originate from luminal epithelial cells |
| url | https://doi.org/10.1038/s41467-021-23957-5 |
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