The emerging roles of long non-coding RNA (lncRNA) H19 in gynecologic cancers
Abstract Long non-coding RNA (lncRNA) H19 has gained significant recognition as a pivotal contributor to the initiation and advancement of gynecologic cancers, encompassing ovarian, endometrial, cervical, and breast cancers. H19 exhibits a complex array of mechanisms, demonstrating dualistic effects...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-01-01
|
| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12885-023-11743-z |
| _version_ | 1797363236336566272 |
|---|---|
| author | Majid Ghasemian Mojtaba Zehtabi Mahrokh Abouali Gale Dari Fatemeh Khojasteh Pour Ghasem Azizi Tabesh Farideh Moramezi Razieh Mohammad Jafari Mojgan Barati Shahab Uddin Maryam Farzaneh |
| author_facet | Majid Ghasemian Mojtaba Zehtabi Mahrokh Abouali Gale Dari Fatemeh Khojasteh Pour Ghasem Azizi Tabesh Farideh Moramezi Razieh Mohammad Jafari Mojgan Barati Shahab Uddin Maryam Farzaneh |
| author_sort | Majid Ghasemian |
| collection | DOAJ |
| description | Abstract Long non-coding RNA (lncRNA) H19 has gained significant recognition as a pivotal contributor to the initiation and advancement of gynecologic cancers, encompassing ovarian, endometrial, cervical, and breast cancers. H19 exhibits a complex array of mechanisms, demonstrating dualistic effects on tumorigenesis as it can function as both an oncogene and a tumor suppressor, contingent upon the specific context and type of cancer being investigated. In ovarian cancer, H19 promotes tumor growth, metastasis, and chemoresistance through modulation of key signaling pathways and interaction with microRNAs. Conversely, in endometrial cancer, H19 acts as a tumor suppressor by inhibiting proliferation, inducing apoptosis, and regulating epithelial-mesenchymal transition. Additionally, H19 has been implicated in cervical and breast cancers, where it influences cell proliferation, invasion, and immune evasion. Moreover, H19 has potential as a diagnostic and prognostic biomarker for gynecologic cancers, with its expression levels correlating with clinical parameters and patient outcomes. Understanding the functional roles of H19 in gynecologic cancers is crucial for the development of targeted therapeutic strategies and personalized treatment approaches. Further investigation into the intricate molecular mechanisms underlying H19’s involvement in gynecologic malignancies is warranted to fully unravel its therapeutic potential and clinical implications. This review aims to elucidate the functional roles of H19 in various gynecologic malignancies. |
| first_indexed | 2024-03-08T16:17:22Z |
| format | Article |
| id | doaj.art-73ba8c894bbd4639aad2f22395a45f99 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-03-08T16:17:22Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-73ba8c894bbd4639aad2f22395a45f992024-01-07T12:30:00ZengBMCBMC Cancer1471-24072024-01-0124111410.1186/s12885-023-11743-zThe emerging roles of long non-coding RNA (lncRNA) H19 in gynecologic cancersMajid Ghasemian0Mojtaba Zehtabi1Mahrokh Abouali Gale Dari2Fatemeh Khojasteh Pour3Ghasem Azizi Tabesh4Farideh Moramezi5Razieh Mohammad Jafari6Mojgan Barati7Shahab Uddin8Maryam Farzaneh9Department of Clinical Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical SciencesHematology and Oncology Research Center, Tabriz University of Medical SciencesDepartment of Obstetrics and Gynecology, School of Medicine, Ahvaz Jundishapur University of Medical SciencesDepartment of Obstetrics and Gynecology, School of Medicine, Hamadan University of Medical SciencesGenomic Research Center, Shahid Beheshti University of Medical SciencesFertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical SciencesFertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical SciencesFertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical SciencesTranslational Institute and Dermatology Institute, Academic Health System, Hamad Medical CorporationFertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical SciencesAbstract Long non-coding RNA (lncRNA) H19 has gained significant recognition as a pivotal contributor to the initiation and advancement of gynecologic cancers, encompassing ovarian, endometrial, cervical, and breast cancers. H19 exhibits a complex array of mechanisms, demonstrating dualistic effects on tumorigenesis as it can function as both an oncogene and a tumor suppressor, contingent upon the specific context and type of cancer being investigated. In ovarian cancer, H19 promotes tumor growth, metastasis, and chemoresistance through modulation of key signaling pathways and interaction with microRNAs. Conversely, in endometrial cancer, H19 acts as a tumor suppressor by inhibiting proliferation, inducing apoptosis, and regulating epithelial-mesenchymal transition. Additionally, H19 has been implicated in cervical and breast cancers, where it influences cell proliferation, invasion, and immune evasion. Moreover, H19 has potential as a diagnostic and prognostic biomarker for gynecologic cancers, with its expression levels correlating with clinical parameters and patient outcomes. Understanding the functional roles of H19 in gynecologic cancers is crucial for the development of targeted therapeutic strategies and personalized treatment approaches. Further investigation into the intricate molecular mechanisms underlying H19’s involvement in gynecologic malignancies is warranted to fully unravel its therapeutic potential and clinical implications. This review aims to elucidate the functional roles of H19 in various gynecologic malignancies.https://doi.org/10.1186/s12885-023-11743-zLncRNAsH19Gynecologic cancerTumorigenesisBiomarker |
| spellingShingle | Majid Ghasemian Mojtaba Zehtabi Mahrokh Abouali Gale Dari Fatemeh Khojasteh Pour Ghasem Azizi Tabesh Farideh Moramezi Razieh Mohammad Jafari Mojgan Barati Shahab Uddin Maryam Farzaneh The emerging roles of long non-coding RNA (lncRNA) H19 in gynecologic cancers BMC Cancer LncRNAs H19 Gynecologic cancer Tumorigenesis Biomarker |
| title | The emerging roles of long non-coding RNA (lncRNA) H19 in gynecologic cancers |
| title_full | The emerging roles of long non-coding RNA (lncRNA) H19 in gynecologic cancers |
| title_fullStr | The emerging roles of long non-coding RNA (lncRNA) H19 in gynecologic cancers |
| title_full_unstemmed | The emerging roles of long non-coding RNA (lncRNA) H19 in gynecologic cancers |
| title_short | The emerging roles of long non-coding RNA (lncRNA) H19 in gynecologic cancers |
| title_sort | emerging roles of long non coding rna lncrna h19 in gynecologic cancers |
| topic | LncRNAs H19 Gynecologic cancer Tumorigenesis Biomarker |
| url | https://doi.org/10.1186/s12885-023-11743-z |
| work_keys_str_mv | AT majidghasemian theemergingrolesoflongnoncodingrnalncrnah19ingynecologiccancers AT mojtabazehtabi theemergingrolesoflongnoncodingrnalncrnah19ingynecologiccancers AT mahrokhaboualigaledari theemergingrolesoflongnoncodingrnalncrnah19ingynecologiccancers AT fatemehkhojastehpour theemergingrolesoflongnoncodingrnalncrnah19ingynecologiccancers AT ghasemazizitabesh theemergingrolesoflongnoncodingrnalncrnah19ingynecologiccancers AT faridehmoramezi theemergingrolesoflongnoncodingrnalncrnah19ingynecologiccancers AT raziehmohammadjafari theemergingrolesoflongnoncodingrnalncrnah19ingynecologiccancers AT mojganbarati theemergingrolesoflongnoncodingrnalncrnah19ingynecologiccancers AT shahabuddin theemergingrolesoflongnoncodingrnalncrnah19ingynecologiccancers AT maryamfarzaneh theemergingrolesoflongnoncodingrnalncrnah19ingynecologiccancers AT majidghasemian emergingrolesoflongnoncodingrnalncrnah19ingynecologiccancers AT mojtabazehtabi emergingrolesoflongnoncodingrnalncrnah19ingynecologiccancers AT mahrokhaboualigaledari emergingrolesoflongnoncodingrnalncrnah19ingynecologiccancers AT fatemehkhojastehpour emergingrolesoflongnoncodingrnalncrnah19ingynecologiccancers AT ghasemazizitabesh emergingrolesoflongnoncodingrnalncrnah19ingynecologiccancers AT faridehmoramezi emergingrolesoflongnoncodingrnalncrnah19ingynecologiccancers AT raziehmohammadjafari emergingrolesoflongnoncodingrnalncrnah19ingynecologiccancers AT mojganbarati emergingrolesoflongnoncodingrnalncrnah19ingynecologiccancers AT shahabuddin emergingrolesoflongnoncodingrnalncrnah19ingynecologiccancers AT maryamfarzaneh emergingrolesoflongnoncodingrnalncrnah19ingynecologiccancers |