Alterations in T and B Cell Receptor Repertoires Patterns in Patients With IL10 Signaling Defects and History of Infantile-Onset IBD

Alterations in T and B Cell Receptor Repertoires Patterns in Patients With IL10 Signaling Defects and History of Infantile-Onset IBD

Patients with loss-of-function mutations in IL10 or IL10 receptor (IL10R) genes develop severe, medical-refractory, infantile-onset inflammatory bowel disease (IBD). We have previously reported significant alterations in innate and adaptive immune responses in these patients. Next generation sequenc...

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Bibliographic Details
Main Authors: Lael Werner, Yu Nee Lee, Erez Rechavi, Atar Lev, Baruch Yerushalmi, Galina Ling, Neil Shah, Holm H. Uhlig, Batia Weiss, Raz Somech, Scott B. Snapper, Dror S. Shouval
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
IBD
VEOIBD
NGS
T cell receptor repertoire
B cell receptor repertoire
IL10
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00109/full

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