Bloodstream Infections in Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis
Background: Little is known about the occurrence of bloodstream infections in hospitalized patients with COVID-19 and the related clinical consequences. The aim of this systematic review and meta-analysis was to estimate the pooled occurrence of BSIs among hospitalized patients with COVID-19 and mor...
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MDPI AG
2021-09-01
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Online Access: | https://www.mdpi.com/2076-2607/9/10/2016 |
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author | Mariachiara Ippolito Barbara Simone Carlotta Filisina Francesca Romana Catalanotto Giulia Catalisano Claudia Marino Giovanni Misseri Antonino Giarratano Andrea Cortegiani |
author_facet | Mariachiara Ippolito Barbara Simone Carlotta Filisina Francesca Romana Catalanotto Giulia Catalisano Claudia Marino Giovanni Misseri Antonino Giarratano Andrea Cortegiani |
author_sort | Mariachiara Ippolito |
collection | DOAJ |
description | Background: Little is known about the occurrence of bloodstream infections in hospitalized patients with COVID-19 and the related clinical consequences. The aim of this systematic review and meta-analysis was to estimate the pooled occurrence of BSIs among hospitalized patients with COVID-19 and mortality of this patient population. Methods: A systematic search was performed on PubMed, EMBASE, and Web of Science from inception to 19 April 2021. The primary outcome was the occurrence of BSIs among hospitalized patients with COVID-19. The secondary outcome was mortality at the longest available follow-up. Results: Forty-six studies met the inclusion criteria, with a total of 42,694 patients evaluated. The estimated occurrence of BSIs was 7.3% (95% CI 4.7–1.1%) among hospitalized patients with COVID-19, with a mortality rate of 41% (95% CI 30%–52.8%). The subgroup analysis conducted on patients admitted to ICU provided an estimated occurrence of 29.6% (95% CI 21.7%–38.8%). A higher occurrence of BSI was observed in patients with COVID-19, in comparison with patients without COVID-19 (OR 2.77; 95% CI 1.53–5.02; <i>p</i> < 0.001). Conclusions: Our analysis estimated the occurrence of BSIs among hospitalized patients with COVID-19 at around 7%. A four-times higher occurrence was estimated among patients admitted to ICU. |
first_indexed | 2024-03-10T06:22:05Z |
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institution | Directory Open Access Journal |
issn | 2076-2607 |
language | English |
last_indexed | 2024-03-10T06:22:05Z |
publishDate | 2021-09-01 |
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series | Microorganisms |
spelling | doaj.art-73bc06130cda470e87ce4f7bd1b5f4a62023-11-22T19:12:53ZengMDPI AGMicroorganisms2076-26072021-09-01910201610.3390/microorganisms9102016Bloodstream Infections in Hospitalized Patients with COVID-19: A Systematic Review and Meta-AnalysisMariachiara Ippolito0Barbara Simone1Carlotta Filisina2Francesca Romana Catalanotto3Giulia Catalisano4Claudia Marino5Giovanni Misseri6Antonino Giarratano7Andrea Cortegiani8Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), University of Palermo, 90127 Palermo, ItalyDepartment of Surgical, Oncological and Oral Science (Di.Chir.On.S.), University of Palermo, 90127 Palermo, ItalyDepartment of Surgical, Oncological and Oral Science (Di.Chir.On.S.), University of Palermo, 90127 Palermo, ItalyDepartment of Surgical, Oncological and Oral Science (Di.Chir.On.S.), University of Palermo, 90127 Palermo, ItalyDepartment of Surgical, Oncological and Oral Science (Di.Chir.On.S.), University of Palermo, 90127 Palermo, ItalyDepartment of Surgical, Oncological and Oral Science (Di.Chir.On.S.), University of Palermo, 90127 Palermo, ItalyFondazione Giglio, 90015 Cefalù, ItalyDepartment of Surgical, Oncological and Oral Science (Di.Chir.On.S.), University of Palermo, 90127 Palermo, ItalyDepartment of Surgical, Oncological and Oral Science (Di.Chir.On.S.), University of Palermo, 90127 Palermo, ItalyBackground: Little is known about the occurrence of bloodstream infections in hospitalized patients with COVID-19 and the related clinical consequences. The aim of this systematic review and meta-analysis was to estimate the pooled occurrence of BSIs among hospitalized patients with COVID-19 and mortality of this patient population. Methods: A systematic search was performed on PubMed, EMBASE, and Web of Science from inception to 19 April 2021. The primary outcome was the occurrence of BSIs among hospitalized patients with COVID-19. The secondary outcome was mortality at the longest available follow-up. Results: Forty-six studies met the inclusion criteria, with a total of 42,694 patients evaluated. The estimated occurrence of BSIs was 7.3% (95% CI 4.7–1.1%) among hospitalized patients with COVID-19, with a mortality rate of 41% (95% CI 30%–52.8%). The subgroup analysis conducted on patients admitted to ICU provided an estimated occurrence of 29.6% (95% CI 21.7%–38.8%). A higher occurrence of BSI was observed in patients with COVID-19, in comparison with patients without COVID-19 (OR 2.77; 95% CI 1.53–5.02; <i>p</i> < 0.001). Conclusions: Our analysis estimated the occurrence of BSIs among hospitalized patients with COVID-19 at around 7%. A four-times higher occurrence was estimated among patients admitted to ICU.https://www.mdpi.com/2076-2607/9/10/2016bloodstream infectionsCOVID-19review |
spellingShingle | Mariachiara Ippolito Barbara Simone Carlotta Filisina Francesca Romana Catalanotto Giulia Catalisano Claudia Marino Giovanni Misseri Antonino Giarratano Andrea Cortegiani Bloodstream Infections in Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis Microorganisms bloodstream infections COVID-19 review |
title | Bloodstream Infections in Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis |
title_full | Bloodstream Infections in Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis |
title_fullStr | Bloodstream Infections in Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis |
title_full_unstemmed | Bloodstream Infections in Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis |
title_short | Bloodstream Infections in Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis |
title_sort | bloodstream infections in hospitalized patients with covid 19 a systematic review and meta analysis |
topic | bloodstream infections COVID-19 review |
url | https://www.mdpi.com/2076-2607/9/10/2016 |
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