Low cost biological lung volume reduction therapy for advanced emphysema
Mostafa Bakeer,1 Taha Taha Abdelgawad,1 Raed El-Metwaly,1 Ahmed El-Morsi,1 Mohammad Khairy El-Badrawy,1 Solafa El-Sharawy2 1Chest Medicine Department, 2Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt Background: Bronchoscopic lung volume reduction (BLVR), usi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2016-08-01
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| Series: | International Journal of COPD |
| Subjects: | |
| Online Access: | https://www.dovepress.com/low-cost-biological-lung-volume-reduction-therapy-for-advanced-emphyse-peer-reviewed-article-COPD |
| _version_ | 1811207748340154368 |
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| author | Bakeer M Abdelgawad TT El-Metwaly R El-Morsi A El-Badrawy MK El-Sharawy S |
| author_facet | Bakeer M Abdelgawad TT El-Metwaly R El-Morsi A El-Badrawy MK El-Sharawy S |
| author_sort | Bakeer M |
| collection | DOAJ |
| description | Mostafa Bakeer,1 Taha Taha Abdelgawad,1 Raed El-Metwaly,1 Ahmed El-Morsi,1 Mohammad Khairy El-Badrawy,1 Solafa El-Sharawy2 1Chest Medicine Department, 2Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt Background: Bronchoscopic lung volume reduction (BLVR), using biological agents, is one of the new alternatives to lung volume reduction surgery.Objectives: To evaluate efficacy and safety of biological BLVR using low cost agents including autologous blood and fibrin glue.Methods: Enrolled patients were divided into two groups: group A (seven patients) in which autologous blood was used and group B (eight patients) in which fibrin glue was used. The agents were injected through a triple lumen balloon catheter via fiberoptic bronchoscope. Changes in high resolution computerized tomography (HRCT) volumetry, pulmonary function tests, symptoms, and exercise capacity were evaluated at 12 weeks postprocedure as well as for complications.Results: In group A, at 12 weeks postprocedure, there was significant improvement in the mean value of HRCT volumetry and residual volume/total lung capacity (% predicted) (P-value: <0.001 and 0.038, respectively). In group B, there was significant improvement in the mean value of HRCT volumetry and (residual volume/total lung capacity % predicted) (P-value: 0.005 and 0.004, respectively). All patients tolerated the procedure with no mortality.Conclusion: BLVR using autologous blood and locally prepared fibrin glue is a promising method for therapy of advanced emphysema in term of efficacy, safety as well as cost effectiveness. Keywords: BLVR, bronchoscopy, COPD, interventional pulmonology |
| first_indexed | 2024-04-12T04:09:45Z |
| format | Article |
| id | doaj.art-73bcb874230849f6b35519cf0cf853bb |
| institution | Directory Open Access Journal |
| issn | 1178-2005 |
| language | English |
| last_indexed | 2024-04-12T04:09:45Z |
| publishDate | 2016-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of COPD |
| spelling | doaj.art-73bcb874230849f6b35519cf0cf853bb2022-12-22T03:48:32ZengDove Medical PressInternational Journal of COPD1178-20052016-08-012016Issue 11793180028237Low cost biological lung volume reduction therapy for advanced emphysemaBakeer MAbdelgawad TTEl-Metwaly REl-Morsi AEl-Badrawy MKEl-Sharawy SMostafa Bakeer,1 Taha Taha Abdelgawad,1 Raed El-Metwaly,1 Ahmed El-Morsi,1 Mohammad Khairy El-Badrawy,1 Solafa El-Sharawy2 1Chest Medicine Department, 2Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt Background: Bronchoscopic lung volume reduction (BLVR), using biological agents, is one of the new alternatives to lung volume reduction surgery.Objectives: To evaluate efficacy and safety of biological BLVR using low cost agents including autologous blood and fibrin glue.Methods: Enrolled patients were divided into two groups: group A (seven patients) in which autologous blood was used and group B (eight patients) in which fibrin glue was used. The agents were injected through a triple lumen balloon catheter via fiberoptic bronchoscope. Changes in high resolution computerized tomography (HRCT) volumetry, pulmonary function tests, symptoms, and exercise capacity were evaluated at 12 weeks postprocedure as well as for complications.Results: In group A, at 12 weeks postprocedure, there was significant improvement in the mean value of HRCT volumetry and residual volume/total lung capacity (% predicted) (P-value: <0.001 and 0.038, respectively). In group B, there was significant improvement in the mean value of HRCT volumetry and (residual volume/total lung capacity % predicted) (P-value: 0.005 and 0.004, respectively). All patients tolerated the procedure with no mortality.Conclusion: BLVR using autologous blood and locally prepared fibrin glue is a promising method for therapy of advanced emphysema in term of efficacy, safety as well as cost effectiveness. Keywords: BLVR, bronchoscopy, COPD, interventional pulmonologyhttps://www.dovepress.com/low-cost-biological-lung-volume-reduction-therapy-for-advanced-emphyse-peer-reviewed-article-COPDBLVRbronchoscopyCOPDInterventional pulmonology |
| spellingShingle | Bakeer M Abdelgawad TT El-Metwaly R El-Morsi A El-Badrawy MK El-Sharawy S Low cost biological lung volume reduction therapy for advanced emphysema International Journal of COPD BLVR bronchoscopy COPD Interventional pulmonology |
| title | Low cost biological lung volume reduction therapy for advanced emphysema |
| title_full | Low cost biological lung volume reduction therapy for advanced emphysema |
| title_fullStr | Low cost biological lung volume reduction therapy for advanced emphysema |
| title_full_unstemmed | Low cost biological lung volume reduction therapy for advanced emphysema |
| title_short | Low cost biological lung volume reduction therapy for advanced emphysema |
| title_sort | low cost biological lung volume reduction therapy for advanced emphysema |
| topic | BLVR bronchoscopy COPD Interventional pulmonology |
| url | https://www.dovepress.com/low-cost-biological-lung-volume-reduction-therapy-for-advanced-emphyse-peer-reviewed-article-COPD |
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