The extracellular matrix supports breast cancer cell growth under amino acid starvation by promoting tyrosine catabolism.

The extracellular matrix supports breast cancer cell growth under amino acid starvation by promoting tyrosine catabolism.

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Breast tumours are embedded in a collagen I-rich extracellular matrix (ECM) network, where nutrients are scarce due to limited blood flow and elevated tumour growth. Metabolic adaptation is required for cancer cells to endure these conditions. Here, we demonstrated that the presence of ECM supported...

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Bibliographic Details
Main Authors: Mona Nazemi, Bian Yanes, Montserrat Llanses Martinez, Heather J Walker, Khoa Pham, Mark O Collins, Frederic Bard, Elena Rainero
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002406&type=printable

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https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002406&type=printable

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