Non-coding Transcripts from Enhancers: New Insights into Enhancer Activity and Gene Expression Regulation
Long non-coding RNAs (lncRNAs) have gained widespread interest in the past decade owing to their enormous amount and surprising functions implicated in a variety of biological processes. Some lncRNAs exert function as enhancers, i.e., activating gene transcription by serving as the cis-regulatory mo...
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| Format: | Article |
| Language: | English |
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Oxford University Press
2017-06-01
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| Series: | Genomics, Proteomics & Bioinformatics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1672022917300803 |
| _version_ | 1827159276534104064 |
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| author | Hongjun Chen Guangshi Du Xu Song Ling Li |
| author_facet | Hongjun Chen Guangshi Du Xu Song Ling Li |
| author_sort | Hongjun Chen |
| collection | DOAJ |
| description | Long non-coding RNAs (lncRNAs) have gained widespread interest in the past decade owing to their enormous amount and surprising functions implicated in a variety of biological processes. Some lncRNAs exert function as enhancers, i.e., activating gene transcription by serving as the cis-regulatory molecules. Furthermore, recent studies have demonstrated that many enhancer elements can be transcribed and produce RNA molecules, which are termed as enhancer RNAs (eRNAs). The eRNAs are not merely the by-product of the enhancer transcription. In fact, many of them directly exert or regulate enhancer activity in gene activation through diverse mechanisms. Here, we provide an overview of enhancer activity, transcription of enhancer itself, characteristics of eRNAs, as well as their roles in regulating enhancer activity and gene expression. |
| first_indexed | 2024-03-08T17:48:07Z |
| format | Article |
| id | doaj.art-73be1ce55e7b4900815b493684bfccdc |
| institution | Directory Open Access Journal |
| issn | 1672-0229 |
| language | English |
| last_indexed | 2025-03-20T23:54:33Z |
| publishDate | 2017-06-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | Genomics, Proteomics & Bioinformatics |
| spelling | doaj.art-73be1ce55e7b4900815b493684bfccdc2024-08-03T11:58:49ZengOxford University PressGenomics, Proteomics & Bioinformatics1672-02292017-06-0115320120710.1016/j.gpb.2017.02.003Non-coding Transcripts from Enhancers: New Insights into Enhancer Activity and Gene Expression RegulationHongjun Chen0Guangshi Du1Xu Song2Ling Li3Center for Functional Genomics and Bioinformatics, Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, ChinaCenter for Functional Genomics and Bioinformatics, Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, ChinaCenter for Functional Genomics and Bioinformatics, Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, ChinaCenter for Functional Genomics and Bioinformatics, Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, ChinaLong non-coding RNAs (lncRNAs) have gained widespread interest in the past decade owing to their enormous amount and surprising functions implicated in a variety of biological processes. Some lncRNAs exert function as enhancers, i.e., activating gene transcription by serving as the cis-regulatory molecules. Furthermore, recent studies have demonstrated that many enhancer elements can be transcribed and produce RNA molecules, which are termed as enhancer RNAs (eRNAs). The eRNAs are not merely the by-product of the enhancer transcription. In fact, many of them directly exert or regulate enhancer activity in gene activation through diverse mechanisms. Here, we provide an overview of enhancer activity, transcription of enhancer itself, characteristics of eRNAs, as well as their roles in regulating enhancer activity and gene expression.http://www.sciencedirect.com/science/article/pii/S1672022917300803LncRNAEnhancer transcriptioneRNAEnhancer activityGene expression |
| spellingShingle | Hongjun Chen Guangshi Du Xu Song Ling Li Non-coding Transcripts from Enhancers: New Insights into Enhancer Activity and Gene Expression Regulation Genomics, Proteomics & Bioinformatics LncRNA Enhancer transcription eRNA Enhancer activity Gene expression |
| title | Non-coding Transcripts from Enhancers: New Insights into Enhancer Activity and Gene Expression Regulation |
| title_full | Non-coding Transcripts from Enhancers: New Insights into Enhancer Activity and Gene Expression Regulation |
| title_fullStr | Non-coding Transcripts from Enhancers: New Insights into Enhancer Activity and Gene Expression Regulation |
| title_full_unstemmed | Non-coding Transcripts from Enhancers: New Insights into Enhancer Activity and Gene Expression Regulation |
| title_short | Non-coding Transcripts from Enhancers: New Insights into Enhancer Activity and Gene Expression Regulation |
| title_sort | non coding transcripts from enhancers new insights into enhancer activity and gene expression regulation |
| topic | LncRNA Enhancer transcription eRNA Enhancer activity Gene expression |
| url | http://www.sciencedirect.com/science/article/pii/S1672022917300803 |
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