Large-scale analysis of network bistability for human cancers.
Protein-protein interaction and gene regulatory networks are likely to be locked in a state corresponding to a disease by the behavior of one or more bistable circuits exhibiting switch-like behavior. Sets of genes could be over-expressed or repressed when anomalies due to disease appear, and the ci...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2010-01-01
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| Series: | PLoS Computational Biology |
| Online Access: | http://europepmc.org/articles/PMC2900289?pdf=render |
| _version_ | 1811338083125166080 |
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| author | Tetsuya Shiraishi Shinako Matsuyama Hiroaki Kitano |
| author_facet | Tetsuya Shiraishi Shinako Matsuyama Hiroaki Kitano |
| author_sort | Tetsuya Shiraishi |
| collection | DOAJ |
| description | Protein-protein interaction and gene regulatory networks are likely to be locked in a state corresponding to a disease by the behavior of one or more bistable circuits exhibiting switch-like behavior. Sets of genes could be over-expressed or repressed when anomalies due to disease appear, and the circuits responsible for this over- or under-expression might persist for as long as the disease state continues. This paper shows how a large-scale analysis of network bistability for various human cancers can identify genes that can potentially serve as drug targets or diagnosis biomarkers. |
| first_indexed | 2024-04-13T18:05:29Z |
| format | Article |
| id | doaj.art-73bff715e6834fb2b161642bc0a3c513 |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-04-13T18:05:29Z |
| publishDate | 2010-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-73bff715e6834fb2b161642bc0a3c5132022-12-22T02:36:05ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582010-01-0167e100085110.1371/journal.pcbi.1000851Large-scale analysis of network bistability for human cancers.Tetsuya ShiraishiShinako MatsuyamaHiroaki KitanoProtein-protein interaction and gene regulatory networks are likely to be locked in a state corresponding to a disease by the behavior of one or more bistable circuits exhibiting switch-like behavior. Sets of genes could be over-expressed or repressed when anomalies due to disease appear, and the circuits responsible for this over- or under-expression might persist for as long as the disease state continues. This paper shows how a large-scale analysis of network bistability for various human cancers can identify genes that can potentially serve as drug targets or diagnosis biomarkers.http://europepmc.org/articles/PMC2900289?pdf=render |
| spellingShingle | Tetsuya Shiraishi Shinako Matsuyama Hiroaki Kitano Large-scale analysis of network bistability for human cancers. PLoS Computational Biology |
| title | Large-scale analysis of network bistability for human cancers. |
| title_full | Large-scale analysis of network bistability for human cancers. |
| title_fullStr | Large-scale analysis of network bistability for human cancers. |
| title_full_unstemmed | Large-scale analysis of network bistability for human cancers. |
| title_short | Large-scale analysis of network bistability for human cancers. |
| title_sort | large scale analysis of network bistability for human cancers |
| url | http://europepmc.org/articles/PMC2900289?pdf=render |
| work_keys_str_mv | AT tetsuyashiraishi largescaleanalysisofnetworkbistabilityforhumancancers AT shinakomatsuyama largescaleanalysisofnetworkbistabilityforhumancancers AT hiroakikitano largescaleanalysisofnetworkbistabilityforhumancancers |