Incidence of Myocardial Injury in COVID-19-Infected Patients: A Systematic Review and Meta-Analysis
<b>Introduction:</b> The incidence of acute myocardial injury (AMI) among Coronavirus Disease 19 (COVID-19)-infected patients remain unclear. We aimed to conduct a systematic review and meta-analysis to further explore the incidence AMI in these patients. <b>Methods:</b> We c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Diseases |
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| Online Access: | https://www.mdpi.com/2079-9721/8/4/40 |
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| author | Narut Prasitlumkum Ronpichai Chokesuwattanaskul Charat Thongprayoon Tarun Bathini Saraschandra Vallabhajosyula Wisit Cheungpasitporn |
| author_facet | Narut Prasitlumkum Ronpichai Chokesuwattanaskul Charat Thongprayoon Tarun Bathini Saraschandra Vallabhajosyula Wisit Cheungpasitporn |
| author_sort | Narut Prasitlumkum |
| collection | DOAJ |
| description | <b>Introduction:</b> The incidence of acute myocardial injury (AMI) among Coronavirus Disease 19 (COVID-19)-infected patients remain unclear. We aimed to conduct a systematic review and meta-analysis to further explore the incidence AMI in these patients. <b>Methods:</b> We comprehensively searched the MEDLINE, EMBASE and Cochrane databases from their inception to August 2020. The included studies were prospective or retrospective cohort studies that reported the event rate of AMI in COVID-19 patients. Data from each study were combined using random-effects to calculate the pooled incidence with 95% confidence intervals. <b>Results:</b> We identified twenty-seven studies consisting of 8971 hospitalized COVID-19-infected patients. The study demonstrated that 20.0% (95% CI 16.1–23.8% with substantial heterogeneity (I<sup>2</sup> = 94.9%)) of hospitalized COVID-19 patients had AMI. In addition, our meta-regression suggested that older age, male and comorbidities were associated with a higher risk of AMI. <b>Conclusion:</b> The incidence of COVID-19-related myocardial injury ranges from 16.1–23.8%. Further larger studies are anticipated, as the pandemic is still ongoing. |
| first_indexed | 2024-03-10T15:18:48Z |
| format | Article |
| id | doaj.art-73c1fc93709a474ab71b5990b8a4e0e7 |
| institution | Directory Open Access Journal |
| issn | 2079-9721 |
| language | English |
| last_indexed | 2024-03-10T15:18:48Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diseases |
| spelling | doaj.art-73c1fc93709a474ab71b5990b8a4e0e72023-11-20T18:40:14ZengMDPI AGDiseases2079-97212020-10-01844010.3390/diseases8040040Incidence of Myocardial Injury in COVID-19-Infected Patients: A Systematic Review and Meta-AnalysisNarut Prasitlumkum0Ronpichai Chokesuwattanaskul1Charat Thongprayoon2Tarun Bathini3Saraschandra Vallabhajosyula4Wisit Cheungpasitporn5Department of Medicine, University of Riverside, Riverside, CA 92521, USAFaculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok 10330, ThailandDepartment of Medicine, Mayo Clinic, Rochester, MN 55905, USADepartment of Internal Medicine, University of Arizona, Tucson, AZ 85721, USADepartment of Cardiovascular Medicine, Emory University, Atlanta, GA 30322, USADepartment of Medicine, Mayo Clinic, Rochester, MN 55905, USA<b>Introduction:</b> The incidence of acute myocardial injury (AMI) among Coronavirus Disease 19 (COVID-19)-infected patients remain unclear. We aimed to conduct a systematic review and meta-analysis to further explore the incidence AMI in these patients. <b>Methods:</b> We comprehensively searched the MEDLINE, EMBASE and Cochrane databases from their inception to August 2020. The included studies were prospective or retrospective cohort studies that reported the event rate of AMI in COVID-19 patients. Data from each study were combined using random-effects to calculate the pooled incidence with 95% confidence intervals. <b>Results:</b> We identified twenty-seven studies consisting of 8971 hospitalized COVID-19-infected patients. The study demonstrated that 20.0% (95% CI 16.1–23.8% with substantial heterogeneity (I<sup>2</sup> = 94.9%)) of hospitalized COVID-19 patients had AMI. In addition, our meta-regression suggested that older age, male and comorbidities were associated with a higher risk of AMI. <b>Conclusion:</b> The incidence of COVID-19-related myocardial injury ranges from 16.1–23.8%. Further larger studies are anticipated, as the pandemic is still ongoing.https://www.mdpi.com/2079-9721/8/4/40coronavirusCOVID-19myocardial injurymeta-analysissystematic review |
| spellingShingle | Narut Prasitlumkum Ronpichai Chokesuwattanaskul Charat Thongprayoon Tarun Bathini Saraschandra Vallabhajosyula Wisit Cheungpasitporn Incidence of Myocardial Injury in COVID-19-Infected Patients: A Systematic Review and Meta-Analysis Diseases coronavirus COVID-19 myocardial injury meta-analysis systematic review |
| title | Incidence of Myocardial Injury in COVID-19-Infected Patients: A Systematic Review and Meta-Analysis |
| title_full | Incidence of Myocardial Injury in COVID-19-Infected Patients: A Systematic Review and Meta-Analysis |
| title_fullStr | Incidence of Myocardial Injury in COVID-19-Infected Patients: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Incidence of Myocardial Injury in COVID-19-Infected Patients: A Systematic Review and Meta-Analysis |
| title_short | Incidence of Myocardial Injury in COVID-19-Infected Patients: A Systematic Review and Meta-Analysis |
| title_sort | incidence of myocardial injury in covid 19 infected patients a systematic review and meta analysis |
| topic | coronavirus COVID-19 myocardial injury meta-analysis systematic review |
| url | https://www.mdpi.com/2079-9721/8/4/40 |
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