Low molecular weight fucoidan inhibits hepatocarcinogenesis and nonalcoholic fatty liver disease in zebrafish via ASGR/STAT3/HNF4A signaling

Low molecular weight fucoidan inhibits hepatocarcinogenesis and nonalcoholic fatty liver disease in zebrafish via ASGR/STAT3/HNF4A signaling

Abstract Background Hepatocellular carcinoma ranks fourth in cancer‐related mortality currently lacks effective therapeutics. Fucoidan is sulfated polysaccharide that is mainly found in brown seaweeds. In this study, we investigated the effects and mechanisms of low molecular weight fucoidan (i.e. o...

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Bibliographic Details
Main Authors: Szu‐Yuan Wu, Wan‐Yu Yang, Chun‐Chia Cheng, Kuan‐Hao Lin, Bonifasius Putera Sampurna, Suat‐Ming Chan, Chiou‐Hwa Yuh
Format: Article
Language:English
Published: Wiley 2020-12-01
Series:Clinical and Translational Medicine
Subjects:
hepatocellular carcinoma
oligo‐fucoidan
therapeutics
zebrafish
Online Access:https://doi.org/10.1002/ctm2.252

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