Cytokine secretion in children with eosinophilia
There is evidence that eosinophils play a considerable role in the pathogenesis of many diseases (allergic, granulomatous, autoimmune, interstitial, idiopathic, parasitic, neoplastic, and myeloproliferative ones). However, despite the long history of studies of eosinophils, their biological properti...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Ltd. “The National Academy of Pediatric Science and Innovation”
2016-03-01
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| Series: | Rossijskij Vestnik Perinatologii i Pediatrii |
| Subjects: | |
| Online Access: | https://www.ped-perinatology.ru/jour/article/view/72 |
| Summary: | There is evidence that eosinophils play a considerable role in the pathogenesis of many diseases (allergic, granulomatous, autoimmune, interstitial, idiopathic, parasitic, neoplastic, and myeloproliferative ones). However, despite the long history of studies of eosinophils, their biological properties were still little studied. The review summarizes the results of studies dealing with the spectrum of cytokines that are secreted by eosinophils and ensure their pleiotropic effects, including immunomodulation, an effect on tissue homeostasis and repair. It also describes the types of eosinophil secretion of cytokines and their effect on the function of eosinophils themselves. Special attention is paid to the scientific facts of cytokine secretion in allergic diseases in children with eosinophilia and to the pathogenic role of cytokines. |
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| ISSN: | 1027-4065 2500-2228 |