Cuproptosis-related gene signature stratifies lower-grade glioma patients and predicts immune characteristics
Cuproptosis is the most recently discovered type of regulated cell death and is mediated by copper ions. Studies show that cuproptosis plays a significant role in cancer development and progression. Lower-grade gliomas (LGGs) are slow-growing brain tumors. The majority of LGGs progress to high-grade...
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| Format: | Article |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.1036460/full |
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| author | Zihao Zhang Bingcheng Wang Bingcheng Wang Xiaoqin Xu Tao Xin Tao Xin Tao Xin |
| author_facet | Zihao Zhang Bingcheng Wang Bingcheng Wang Xiaoqin Xu Tao Xin Tao Xin Tao Xin |
| author_sort | Zihao Zhang |
| collection | DOAJ |
| description | Cuproptosis is the most recently discovered type of regulated cell death and is mediated by copper ions. Studies show that cuproptosis plays a significant role in cancer development and progression. Lower-grade gliomas (LGGs) are slow-growing brain tumors. The majority of LGGs progress to high-grade glioma, which makes it difficult to predict the prognosis. However, the prognostic value of cuproptosis-related genes (CRGs) in LGG needs to be further explored. mRNA expression profiles and clinical data of LGG patients were collected from public sources for this study. Univariate Cox regression analysis and the least absolute shrinkage and selection operator (LASSO) Cox regression model were used to build a multigene signature that could divide patients into different risk groups. The differences in clinical pathological characteristics, immune infiltration characteristics, and mutation status were evaluated in risk subgroups. In addition, drug sensitivity and immune checkpoint scores were estimated in risk subgroups to provide LGG patients with precision medication. We found that all CRGs were differentially expressed in LGG and normal tissues. Patients were divided into high- and low-risk groups based on the risk score of the CRG signature. Patients in the high-risk group had a considerably lower overall survival rate than those in the low-risk group. According to functional analysis, pathways related to the immune system were enriched, and the immune state differed across the two risk groups. Immune characteristic analysis showed that the immune cell proportion and immune scores were different in the different groups. High-risk group was characterized by low sensitivity to chemotherapy but high sensitivity to immune checkpoint inhibitors. The current study revealed that the novel CRG signature was related to the prognosis, clinicopathological features, immune characteristics, and treatment perference of LGG. |
| first_indexed | 2024-04-11T07:23:16Z |
| format | Article |
| id | doaj.art-73c78f32b15347da8ca679232cd63c7a |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-11T07:23:16Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Genetics |
| spelling | doaj.art-73c78f32b15347da8ca679232cd63c7a2022-12-22T04:37:09ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-10-011310.3389/fgene.2022.10364601036460Cuproptosis-related gene signature stratifies lower-grade glioma patients and predicts immune characteristicsZihao Zhang0Bingcheng Wang1Bingcheng Wang2Xiaoqin Xu3Tao Xin4Tao Xin5Tao Xin6Department of Surgery, Shandong Provincial Hospital, Shandong University, Jinan, ChinaDepartment of Neurosurgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, ChinaShandong Medicine and Health Key Laboratory of Neurosurgery, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, ChinaDepartment of Endocrinology, Shandong Provincial Hospital, Shandong University, Jinan, ChinaDepartment of Neurosurgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, ChinaShandong Medicine and Health Key Laboratory of Neurosurgery, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, ChinaDepartment of Neurosurgery, Jiangxi Provincial People’s Hospital Affiliated to Nanchang University, Nanchang, ChinaCuproptosis is the most recently discovered type of regulated cell death and is mediated by copper ions. Studies show that cuproptosis plays a significant role in cancer development and progression. Lower-grade gliomas (LGGs) are slow-growing brain tumors. The majority of LGGs progress to high-grade glioma, which makes it difficult to predict the prognosis. However, the prognostic value of cuproptosis-related genes (CRGs) in LGG needs to be further explored. mRNA expression profiles and clinical data of LGG patients were collected from public sources for this study. Univariate Cox regression analysis and the least absolute shrinkage and selection operator (LASSO) Cox regression model were used to build a multigene signature that could divide patients into different risk groups. The differences in clinical pathological characteristics, immune infiltration characteristics, and mutation status were evaluated in risk subgroups. In addition, drug sensitivity and immune checkpoint scores were estimated in risk subgroups to provide LGG patients with precision medication. We found that all CRGs were differentially expressed in LGG and normal tissues. Patients were divided into high- and low-risk groups based on the risk score of the CRG signature. Patients in the high-risk group had a considerably lower overall survival rate than those in the low-risk group. According to functional analysis, pathways related to the immune system were enriched, and the immune state differed across the two risk groups. Immune characteristic analysis showed that the immune cell proportion and immune scores were different in the different groups. High-risk group was characterized by low sensitivity to chemotherapy but high sensitivity to immune checkpoint inhibitors. The current study revealed that the novel CRG signature was related to the prognosis, clinicopathological features, immune characteristics, and treatment perference of LGG.https://www.frontiersin.org/articles/10.3389/fgene.2022.1036460/fulllower-grade gliomacuproptosis-related genegene signatureprognosisimmune score |
| spellingShingle | Zihao Zhang Bingcheng Wang Bingcheng Wang Xiaoqin Xu Tao Xin Tao Xin Tao Xin Cuproptosis-related gene signature stratifies lower-grade glioma patients and predicts immune characteristics Frontiers in Genetics lower-grade glioma cuproptosis-related gene gene signature prognosis immune score |
| title | Cuproptosis-related gene signature stratifies lower-grade glioma patients and predicts immune characteristics |
| title_full | Cuproptosis-related gene signature stratifies lower-grade glioma patients and predicts immune characteristics |
| title_fullStr | Cuproptosis-related gene signature stratifies lower-grade glioma patients and predicts immune characteristics |
| title_full_unstemmed | Cuproptosis-related gene signature stratifies lower-grade glioma patients and predicts immune characteristics |
| title_short | Cuproptosis-related gene signature stratifies lower-grade glioma patients and predicts immune characteristics |
| title_sort | cuproptosis related gene signature stratifies lower grade glioma patients and predicts immune characteristics |
| topic | lower-grade glioma cuproptosis-related gene gene signature prognosis immune score |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.1036460/full |
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