DIABETIC NEUROPATHY: MOLECULAR MECHANISMS OF DEVELOPMENT AND POSSIBILITIES FOR PATHOGENETIC THERAPY
The present review summarizes the results of global studies and assesses contribution of hyperglycemia towards formation of neurologic complications in diabetic patients. Hyperglycemia is believed to play a leading role in the formation of neurological complications in diabetes mellitus. However, th...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Scientia Publishing House
2019-04-01
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| Series: | Juvenis Scientia |
| Subjects: |
| _version_ | 1818750114287583232 |
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| author | Hudiakova N.V. Ivanov N.V. Pchelin I.Yu. Shishkin A.N. Vorokhobina N.V. Bayrasheva V.K. Vasilkova V.N. |
| author_facet | Hudiakova N.V. Ivanov N.V. Pchelin I.Yu. Shishkin A.N. Vorokhobina N.V. Bayrasheva V.K. Vasilkova V.N. |
| author_sort | Hudiakova N.V. |
| collection | DOAJ |
| description | The present review summarizes the results of global studies and assesses contribution of hyperglycemia towards formation of neurologic complications in diabetic patients. Hyperglycemia is believed to play a leading role in the formation of neurological complications in diabetes mellitus. However, the achievement of normalization of glycemia level does not ensure the cessation of their development and progression, which indicates a lack of knowledge about the pathogenetic relationships in diabetic neuropathy. Limited understanding of these issues entails the absence of treatment options that effectively affect the course of this complication. Based on the analysis of experimental and clinical studies of recent years, data on the molecular-biological relationships of hyperglycemia with the formation of neurological complications in diabetes mellitus are summarized. The influence of the oxidative and nitrosative stress, advanced glycation end products, the activation of the polyol and hexosamine pathways on the state of the nerve fiber is analyzed. The data on molecular mechanisms of development of diabetic neuropathy are contradictory. On the basis of recent experimental and clinical data we review possibilities for pathogenetic therapy. The problem of oppositely directed effects of treatment is discussed. Clinical rationale is given for declared direction of further studies. |
| first_indexed | 2024-12-18T04:14:31Z |
| format | Article |
| id | doaj.art-73c918b4bf0d4a07abffdb288d3b5297 |
| institution | Directory Open Access Journal |
| issn | 2414-3782 2414-3790 |
| language | English |
| last_indexed | 2024-12-18T04:14:31Z |
| publishDate | 2019-04-01 |
| publisher | Scientia Publishing House |
| record_format | Article |
| series | Juvenis Scientia |
| spelling | doaj.art-73c918b4bf0d4a07abffdb288d3b52972022-12-21T21:21:24ZengScientia Publishing HouseJuvenis Scientia2414-37822414-37902019-04-01481210.32415/jscientia.2019.04.02DIABETIC NEUROPATHY: MOLECULAR MECHANISMS OF DEVELOPMENT AND POSSIBILITIES FOR PATHOGENETIC THERAPYHudiakova N.V.0Ivanov N.V.1Pchelin I.Yu.2Shishkin A.N.3Vorokhobina N.V.4Bayrasheva V.K.5Vasilkova V.N.6Saint Petersburg State UniversityNorth-Western State Medical University named after I. I. MechnikovSaint Petersburg State UniversitySaint Petersburg State UniversityNorth-Western State Medical University named after I. I. MechnikovNational Almazov Medical Research CentreGomel State Medical UniversityThe present review summarizes the results of global studies and assesses contribution of hyperglycemia towards formation of neurologic complications in diabetic patients. Hyperglycemia is believed to play a leading role in the formation of neurological complications in diabetes mellitus. However, the achievement of normalization of glycemia level does not ensure the cessation of their development and progression, which indicates a lack of knowledge about the pathogenetic relationships in diabetic neuropathy. Limited understanding of these issues entails the absence of treatment options that effectively affect the course of this complication. Based on the analysis of experimental and clinical studies of recent years, data on the molecular-biological relationships of hyperglycemia with the formation of neurological complications in diabetes mellitus are summarized. The influence of the oxidative and nitrosative stress, advanced glycation end products, the activation of the polyol and hexosamine pathways on the state of the nerve fiber is analyzed. The data on molecular mechanisms of development of diabetic neuropathy are contradictory. On the basis of recent experimental and clinical data we review possibilities for pathogenetic therapy. The problem of oppositely directed effects of treatment is discussed. Clinical rationale is given for declared direction of further studies.Diabetic neuropathypathogenesispathogenetic therapy |
| spellingShingle | Hudiakova N.V. Ivanov N.V. Pchelin I.Yu. Shishkin A.N. Vorokhobina N.V. Bayrasheva V.K. Vasilkova V.N. DIABETIC NEUROPATHY: MOLECULAR MECHANISMS OF DEVELOPMENT AND POSSIBILITIES FOR PATHOGENETIC THERAPY Juvenis Scientia Diabetic neuropathy pathogenesis pathogenetic therapy |
| title | DIABETIC NEUROPATHY: MOLECULAR MECHANISMS OF DEVELOPMENT AND POSSIBILITIES FOR PATHOGENETIC THERAPY |
| title_full | DIABETIC NEUROPATHY: MOLECULAR MECHANISMS OF DEVELOPMENT AND POSSIBILITIES FOR PATHOGENETIC THERAPY |
| title_fullStr | DIABETIC NEUROPATHY: MOLECULAR MECHANISMS OF DEVELOPMENT AND POSSIBILITIES FOR PATHOGENETIC THERAPY |
| title_full_unstemmed | DIABETIC NEUROPATHY: MOLECULAR MECHANISMS OF DEVELOPMENT AND POSSIBILITIES FOR PATHOGENETIC THERAPY |
| title_short | DIABETIC NEUROPATHY: MOLECULAR MECHANISMS OF DEVELOPMENT AND POSSIBILITIES FOR PATHOGENETIC THERAPY |
| title_sort | diabetic neuropathy molecular mechanisms of development and possibilities for pathogenetic therapy |
| topic | Diabetic neuropathy pathogenesis pathogenetic therapy |
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