Selenium as a Bioactive Micronutrient in the Human Diet and Its Cancer Chemopreventive Activity
This review answers the question of why selenium is such an important trace element in the human diet. Daily dietary intake of selenium and its content in various food products is discussed in this paper, as well as the effects of its deficiency and excess in the body. Moreover, the biological activ...
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| Format: | Article |
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MDPI AG
2021-05-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/5/1649 |
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| author | Dominika Radomska Robert Czarnomysy Dominik Radomski Anna Bielawska Krzysztof Bielawski |
| author_facet | Dominika Radomska Robert Czarnomysy Dominik Radomski Anna Bielawska Krzysztof Bielawski |
| author_sort | Dominika Radomska |
| collection | DOAJ |
| description | This review answers the question of why selenium is such an important trace element in the human diet. Daily dietary intake of selenium and its content in various food products is discussed in this paper, as well as the effects of its deficiency and excess in the body. Moreover, the biological activity of selenium, which it performs mainly through selenoproteins, is discussed. These specific proteins are responsible for thyroid hormone management, fertility, the aging process, and immunity, but their key role is to maintain a redox balance in cells. Furthermore, taking into account world news and the current SARS-CoV-2 virus pandemic, the impact of selenium on the course of COVID-19 is also discussed. Another worldwide problem is the number of new cancer cases and cancer-related mortality. Thus, the last part of the article discusses the impact of selenium on cancer risk based on clinical trials (including NPC and SELECT), systematic reviews, and meta-analyses. Additionally, this review discusses the possible mechanisms of selenium action that prevent cancer development. |
| first_indexed | 2024-03-10T11:25:53Z |
| format | Article |
| id | doaj.art-73cab4eecbfc49ce98657ed1d0c34f8c |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T11:25:53Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-73cab4eecbfc49ce98657ed1d0c34f8c2023-11-21T19:38:18ZengMDPI AGNutrients2072-66432021-05-01135164910.3390/nu13051649Selenium as a Bioactive Micronutrient in the Human Diet and Its Cancer Chemopreventive ActivityDominika Radomska0Robert Czarnomysy1Dominik Radomski2Anna Bielawska3Krzysztof Bielawski4Department of Synthesis and Technology of Drugs, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, PolandDepartment of Synthesis and Technology of Drugs, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, PolandDepartment of Synthesis and Technology of Drugs, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, PolandDepartment of Biotechnology, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, PolandDepartment of Synthesis and Technology of Drugs, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, PolandThis review answers the question of why selenium is such an important trace element in the human diet. Daily dietary intake of selenium and its content in various food products is discussed in this paper, as well as the effects of its deficiency and excess in the body. Moreover, the biological activity of selenium, which it performs mainly through selenoproteins, is discussed. These specific proteins are responsible for thyroid hormone management, fertility, the aging process, and immunity, but their key role is to maintain a redox balance in cells. Furthermore, taking into account world news and the current SARS-CoV-2 virus pandemic, the impact of selenium on the course of COVID-19 is also discussed. Another worldwide problem is the number of new cancer cases and cancer-related mortality. Thus, the last part of the article discusses the impact of selenium on cancer risk based on clinical trials (including NPC and SELECT), systematic reviews, and meta-analyses. Additionally, this review discusses the possible mechanisms of selenium action that prevent cancer development.https://www.mdpi.com/2072-6643/13/5/1649seleniumcancerpreventioncancer chemopreventionmolecular mechanismsmicronutrients |
| spellingShingle | Dominika Radomska Robert Czarnomysy Dominik Radomski Anna Bielawska Krzysztof Bielawski Selenium as a Bioactive Micronutrient in the Human Diet and Its Cancer Chemopreventive Activity Nutrients selenium cancer prevention cancer chemoprevention molecular mechanisms micronutrients |
| title | Selenium as a Bioactive Micronutrient in the Human Diet and Its Cancer Chemopreventive Activity |
| title_full | Selenium as a Bioactive Micronutrient in the Human Diet and Its Cancer Chemopreventive Activity |
| title_fullStr | Selenium as a Bioactive Micronutrient in the Human Diet and Its Cancer Chemopreventive Activity |
| title_full_unstemmed | Selenium as a Bioactive Micronutrient in the Human Diet and Its Cancer Chemopreventive Activity |
| title_short | Selenium as a Bioactive Micronutrient in the Human Diet and Its Cancer Chemopreventive Activity |
| title_sort | selenium as a bioactive micronutrient in the human diet and its cancer chemopreventive activity |
| topic | selenium cancer prevention cancer chemoprevention molecular mechanisms micronutrients |
| url | https://www.mdpi.com/2072-6643/13/5/1649 |
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