Performance and Stability of Tenofovir Alafenamide Formulations within Subcutaneous Biodegradable Implants for HIV Pre-Exposure Prophylaxis (PrEP)

Performance and Stability of Tenofovir Alafenamide Formulations within Subcutaneous Biodegradable Implants for HIV Pre-Exposure Prophylaxis (PrEP)

A critical need exists to develop diverse biomedical strategies for the widespread use of HIV Pre-Exposure Prophylaxis (HIV PrEP). This manuscript describes a subcutaneous reservoir-style implant for long-acting delivery of tenofovir alafenamide (TAF) for HIV PrEP. We detail key parameters of the TA...

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Bibliographic Details
Main Authors: Linying Li, Leah M. Johnson, Sai Archana Krovi, Zach R. Demkovich, Ariane van der Straten
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Pharmaceutics
Subjects:
HIV pre-exposure prophylaxis
tenofovir alafenamide
implant
long-acting drug delivery
poly(ε-caprolactone) (PCL)
biodegradable polymer
Online Access:https://www.mdpi.com/1999-4923/12/11/1057

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