Conserved allosteric inhibition mechanism in SLC1 transporters

Conserved allosteric inhibition mechanism in SLC1 transporters

Excitatory amino acid transporter 1 (EAAT1) is a glutamate transporter belonging to the SLC1 family of solute carriers. It plays a key role in the regulation of the extracellular glutamate concentration in the mammalian brain. The structure of EAAT1 was determined in complex with UCPH-101, apotent,...

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Bibliographic Details
Main Authors: Yang Dong, Jiali Wang, Rachel-Ann Garibsingh, Keino Hutchinson, Yueyue Shi, Gilad Eisenberg, Xiaozhen Yu, Avner Schlessinger, Christof Grewer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-03-01
Series:eLife
Subjects:
SLC1
glutamate transporter
alanine serine cysteine transporter
inhibition
docking
electrophysiology
Online Access:https://elifesciences.org/articles/83464

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