Pregnancy Associated Plasma Protein-A and Placental Growth Factor in a Sub-Saharan African Population: A Nested Cross-Sectional Study.
Baseline distributions of pregnancy disorders' biomarkers PlGF and PAPP-A levels are primarily based on Western European populations of Caucasian ethnicity. Differences in PAPP-A and PlGF concentrations by ethnicity have been observed, with increased levels in Afro-Caribbean, East Asian, and So...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4988712?pdf=render |
| _version_ | 1811267376418652160 |
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| author | Joyce L Browne Kerstin Klipstein-Grobusch Maria P H Koster Dhivya Ramamoorthy Edward Antwi Idder Belmouden Arie Franx Diederick E Grobbee Peter C J I Schielen |
| author_facet | Joyce L Browne Kerstin Klipstein-Grobusch Maria P H Koster Dhivya Ramamoorthy Edward Antwi Idder Belmouden Arie Franx Diederick E Grobbee Peter C J I Schielen |
| author_sort | Joyce L Browne |
| collection | DOAJ |
| description | Baseline distributions of pregnancy disorders' biomarkers PlGF and PAPP-A levels are primarily based on Western European populations of Caucasian ethnicity. Differences in PAPP-A and PlGF concentrations by ethnicity have been observed, with increased levels in Afro-Caribbean, East Asian, and South Asian women. Baseline concentrations of sub-Saharan African women have not been evaluated.To investigate PlGF and PAPP-A in a sub-Saharan African population and assess the performance of existing reference values of PAPP-A and PlGF.A nested cross-sectional study was conducted in two public hospitals in Accra, Ghana. Out of the original 1010 women enrolled in the cohort, 398 participants were eligible for inclusion with a normotensive singleton gestation and serum samples taken between 56-97 days of pregnancy. PAPP-A and PlGF concentrations were measured with an automated immunoassay. Multiple of the median (MoM) values corrected for gestation and maternal weight for PAPP-A and PlGF were calculated using reference values of a Dutch perinatal screening laboratory based on over 10.000 samples, and PlGF manufacturer reference values, respectively.The PAPP-A median MoM was 2.34 (interquartile range (IQR) 1.24-3.97). Median PlGF MoM was 1.25 (IQR 0.95-1.80). Median MoM values for PAPP-A and PlGF tended to be slightly different for various Ghanaian ethnic subgroups.PAPP-A and PlGF MoM values appear to be substantially higher in a sub-Saharan African population compared to the Caucasian or Afro-Caribbean MoM values previously reported. The difference suggests the need for a specific correction factor for this population to avoid underestimation of risk for fetal aneuploidies or placental disorders when using PAPP-A and PlGF MoM for screening purposes. |
| first_indexed | 2024-04-12T21:01:20Z |
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| id | doaj.art-73cd61467cea4bf8aa2539bc495b14be |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T21:01:20Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-73cd61467cea4bf8aa2539bc495b14be2022-12-22T03:16:50ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01118e015959210.1371/journal.pone.0159592Pregnancy Associated Plasma Protein-A and Placental Growth Factor in a Sub-Saharan African Population: A Nested Cross-Sectional Study.Joyce L BrowneKerstin Klipstein-GrobuschMaria P H KosterDhivya RamamoorthyEdward AntwiIdder BelmoudenArie FranxDiederick E GrobbeePeter C J I SchielenBaseline distributions of pregnancy disorders' biomarkers PlGF and PAPP-A levels are primarily based on Western European populations of Caucasian ethnicity. Differences in PAPP-A and PlGF concentrations by ethnicity have been observed, with increased levels in Afro-Caribbean, East Asian, and South Asian women. Baseline concentrations of sub-Saharan African women have not been evaluated.To investigate PlGF and PAPP-A in a sub-Saharan African population and assess the performance of existing reference values of PAPP-A and PlGF.A nested cross-sectional study was conducted in two public hospitals in Accra, Ghana. Out of the original 1010 women enrolled in the cohort, 398 participants were eligible for inclusion with a normotensive singleton gestation and serum samples taken between 56-97 days of pregnancy. PAPP-A and PlGF concentrations were measured with an automated immunoassay. Multiple of the median (MoM) values corrected for gestation and maternal weight for PAPP-A and PlGF were calculated using reference values of a Dutch perinatal screening laboratory based on over 10.000 samples, and PlGF manufacturer reference values, respectively.The PAPP-A median MoM was 2.34 (interquartile range (IQR) 1.24-3.97). Median PlGF MoM was 1.25 (IQR 0.95-1.80). Median MoM values for PAPP-A and PlGF tended to be slightly different for various Ghanaian ethnic subgroups.PAPP-A and PlGF MoM values appear to be substantially higher in a sub-Saharan African population compared to the Caucasian or Afro-Caribbean MoM values previously reported. The difference suggests the need for a specific correction factor for this population to avoid underestimation of risk for fetal aneuploidies or placental disorders when using PAPP-A and PlGF MoM for screening purposes.http://europepmc.org/articles/PMC4988712?pdf=render |
| spellingShingle | Joyce L Browne Kerstin Klipstein-Grobusch Maria P H Koster Dhivya Ramamoorthy Edward Antwi Idder Belmouden Arie Franx Diederick E Grobbee Peter C J I Schielen Pregnancy Associated Plasma Protein-A and Placental Growth Factor in a Sub-Saharan African Population: A Nested Cross-Sectional Study. PLoS ONE |
| title | Pregnancy Associated Plasma Protein-A and Placental Growth Factor in a Sub-Saharan African Population: A Nested Cross-Sectional Study. |
| title_full | Pregnancy Associated Plasma Protein-A and Placental Growth Factor in a Sub-Saharan African Population: A Nested Cross-Sectional Study. |
| title_fullStr | Pregnancy Associated Plasma Protein-A and Placental Growth Factor in a Sub-Saharan African Population: A Nested Cross-Sectional Study. |
| title_full_unstemmed | Pregnancy Associated Plasma Protein-A and Placental Growth Factor in a Sub-Saharan African Population: A Nested Cross-Sectional Study. |
| title_short | Pregnancy Associated Plasma Protein-A and Placental Growth Factor in a Sub-Saharan African Population: A Nested Cross-Sectional Study. |
| title_sort | pregnancy associated plasma protein a and placental growth factor in a sub saharan african population a nested cross sectional study |
| url | http://europepmc.org/articles/PMC4988712?pdf=render |
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