Cardiac Safety of Kinase Inhibitors – Improving Understanding and Prediction of Liabilities in Drug Discovery Using Human Stem Cell-Derived Models

Cardiac Safety of Kinase Inhibitors – Improving Understanding and Prediction of Liabilities in Drug Discovery Using Human Stem Cell-Derived Models

Many small molecule kinase inhibitors (SMKIs) used to fight cancer have been associated with cardiotoxicity in the clinic. Therefore, preventing their failure in clinical development is a priority for preclinical discovery. Our study focused on the integration and concurrent measurement of ATP, apop...

Full description

Bibliographic Details
Main Authors: Ricarda Ziegler, Fabian Häusermann, Stephan Kirchner, Liudmila Polonchuk
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
kinase inhibitors
cardiotoxicity
iPS-derived cardiomyocytes
apoptosis
beating rate
cell impedance
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.639824/full

Similar Items

Similar Items