Histopathological Biocompatibility Evaluation of TheraCal PT, NeoMTA, and MTA Angelus in a Murine Model
The aim of this study was to evaluate the biocompatibility of the regeneration of the dentin–pulp complex in a murine model with different treatments with MTA Angelus, NeoMTA, and TheraCal PT. An in vivo controlled experimental study of 15 male Wistar rats forming three study groups, the upper and l...
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MDPI AG
2023-04-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/14/4/202 |
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| author | Francelia Quiñonez-Ruvalcaba Carlos Bermúdez-Jiménez Luis Alejandro Aguilera-Galavíz Francisco G Villanueva-Sánchez Salvador García-Cruz César Gaitán-Fonseca |
| author_facet | Francelia Quiñonez-Ruvalcaba Carlos Bermúdez-Jiménez Luis Alejandro Aguilera-Galavíz Francisco G Villanueva-Sánchez Salvador García-Cruz César Gaitán-Fonseca |
| author_sort | Francelia Quiñonez-Ruvalcaba |
| collection | DOAJ |
| description | The aim of this study was to evaluate the biocompatibility of the regeneration of the dentin–pulp complex in a murine model with different treatments with MTA Angelus, NeoMTA, and TheraCal PT. An in vivo controlled experimental study of 15 male Wistar rats forming three study groups, the upper and lower central incisors were selected where pulpotomies were conducted, leaving a central incisor as control at 15, 30, and 45 days. For data analysis, these were expressed as mean ± standard deviation and were examined by Kruskal–Wallis test. Three factors were analyzed as follows: “inflammatory infiltrate; disorganization of pulp tissue, and the formation of reparative dentin”. No statistical significance was found between the different groups (<i>p ></i> 0.05). Treatment with these three biomaterials (MTA, TheraCal PT, and Neo MTA) presented an inflammatory infiltrate and slight disorganization of the odontoblast layer in the pulp tissue of a murine model, with normal coronary pulp tissue and the formation of reparative dentin in the three experimental groups. Thus, we are able to conclude that all three are biocompatible materials. |
| first_indexed | 2024-03-11T04:52:59Z |
| format | Article |
| id | doaj.art-73ce87ead2dc4cd6b676bd08d4dbbf40 |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-11T04:52:59Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-73ce87ead2dc4cd6b676bd08d4dbbf402023-11-17T19:53:08ZengMDPI AGJournal of Functional Biomaterials2079-49832023-04-0114420210.3390/jfb14040202Histopathological Biocompatibility Evaluation of TheraCal PT, NeoMTA, and MTA Angelus in a Murine ModelFrancelia Quiñonez-Ruvalcaba0Carlos Bermúdez-Jiménez1Luis Alejandro Aguilera-Galavíz2Francisco G Villanueva-Sánchez3Salvador García-Cruz4César Gaitán-Fonseca5Programa de “Especialidad en Odontopediatría, Unidad Académica de Odontología, Universidad Autónoma de Zacatecas”, Zacatecas 98000, MexicoUnidad Académica de Odontología, Universidad Autónoma de Zacatecas “Francisco García Salinas”, Zacatecas 98000, MexicoPrograma de “Especialidad en Odontopediatría, Unidad Académica de Odontología, Universidad Autónoma de Zacatecas”, Zacatecas 98000, MexicoInterdisciplinary Research Laboratory, Oral and Maxillofacial Pathology Area, Universidad Nacional Autónoma de México, Escuela Nacional de Estudios Superiores Unidad León, León 37684, MexicoFacultad de Medicina Humana y Ciencias de la Salud, Universidad Autónoma de Zacatecas, Zacatecas 98000, MexicoPrograma de “Especialidad en Odontopediatría, Unidad Académica de Odontología, Universidad Autónoma de Zacatecas”, Zacatecas 98000, MexicoThe aim of this study was to evaluate the biocompatibility of the regeneration of the dentin–pulp complex in a murine model with different treatments with MTA Angelus, NeoMTA, and TheraCal PT. An in vivo controlled experimental study of 15 male Wistar rats forming three study groups, the upper and lower central incisors were selected where pulpotomies were conducted, leaving a central incisor as control at 15, 30, and 45 days. For data analysis, these were expressed as mean ± standard deviation and were examined by Kruskal–Wallis test. Three factors were analyzed as follows: “inflammatory infiltrate; disorganization of pulp tissue, and the formation of reparative dentin”. No statistical significance was found between the different groups (<i>p ></i> 0.05). Treatment with these three biomaterials (MTA, TheraCal PT, and Neo MTA) presented an inflammatory infiltrate and slight disorganization of the odontoblast layer in the pulp tissue of a murine model, with normal coronary pulp tissue and the formation of reparative dentin in the three experimental groups. Thus, we are able to conclude that all three are biocompatible materials.https://www.mdpi.com/2079-4983/14/4/202cellular inflammatory infiltratepulp tissue disorganizationreparative dentinpulpotomymurine model |
| spellingShingle | Francelia Quiñonez-Ruvalcaba Carlos Bermúdez-Jiménez Luis Alejandro Aguilera-Galavíz Francisco G Villanueva-Sánchez Salvador García-Cruz César Gaitán-Fonseca Histopathological Biocompatibility Evaluation of TheraCal PT, NeoMTA, and MTA Angelus in a Murine Model Journal of Functional Biomaterials cellular inflammatory infiltrate pulp tissue disorganization reparative dentin pulpotomy murine model |
| title | Histopathological Biocompatibility Evaluation of TheraCal PT, NeoMTA, and MTA Angelus in a Murine Model |
| title_full | Histopathological Biocompatibility Evaluation of TheraCal PT, NeoMTA, and MTA Angelus in a Murine Model |
| title_fullStr | Histopathological Biocompatibility Evaluation of TheraCal PT, NeoMTA, and MTA Angelus in a Murine Model |
| title_full_unstemmed | Histopathological Biocompatibility Evaluation of TheraCal PT, NeoMTA, and MTA Angelus in a Murine Model |
| title_short | Histopathological Biocompatibility Evaluation of TheraCal PT, NeoMTA, and MTA Angelus in a Murine Model |
| title_sort | histopathological biocompatibility evaluation of theracal pt neomta and mta angelus in a murine model |
| topic | cellular inflammatory infiltrate pulp tissue disorganization reparative dentin pulpotomy murine model |
| url | https://www.mdpi.com/2079-4983/14/4/202 |
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