Levetiracetam-induced interstitial lung disease in a patient with advanced lung cancer
An 85-year-old woman with antibiotics-resistant pneumonia after surgery for metastatic brain tumor from lung cancer was consulted to our department. Chest CT showed diffuse GGO bilaterally. BALF showed elevated ratios of lymphocytes and CD4/CD8. Tests for bacteria, mycobacteria, and fungi were negat...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-01-01
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| Series: | Respiratory Medicine Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221300712030455X |
| _version_ | 1818380818642370560 |
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| author | Shintaro Sato Tomohiro Oba Hiroki Ohta Yuta Tsukahara Gen Kida Emiri Tsumiyama Kenji Kusano Tomotaka Nishizawa Rie Kawabe Hideaki Yamakawa Keiichi Akasaka Masako Amano Hidekazu Matsushima |
| author_facet | Shintaro Sato Tomohiro Oba Hiroki Ohta Yuta Tsukahara Gen Kida Emiri Tsumiyama Kenji Kusano Tomotaka Nishizawa Rie Kawabe Hideaki Yamakawa Keiichi Akasaka Masako Amano Hidekazu Matsushima |
| author_sort | Shintaro Sato |
| collection | DOAJ |
| description | An 85-year-old woman with antibiotics-resistant pneumonia after surgery for metastatic brain tumor from lung cancer was consulted to our department. Chest CT showed diffuse GGO bilaterally. BALF showed elevated ratios of lymphocytes and CD4/CD8. Tests for bacteria, mycobacteria, and fungi were negative. She improved following levetiracetam discontinuance and systemic corticosteroid administration, and we diagnosed levetiracetam-induced lung injury. Although levetiracetam is widely used, few reports of levetiracetam-induced pneumonia exist. Changes in chest images may occur after levetiracetam administration if patients have multiple risk factors for development of drug-induced interstitial lung disease. Bronchoscopy is useful for differential diagnosis if new lung lesions appear after starting levetiracetam. |
| first_indexed | 2024-12-14T02:24:44Z |
| format | Article |
| id | doaj.art-73d1decad5bb45839288ecbbdb39c2dd |
| institution | Directory Open Access Journal |
| issn | 2213-0071 |
| language | English |
| last_indexed | 2024-12-14T02:24:44Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj.art-73d1decad5bb45839288ecbbdb39c2dd2022-12-21T23:20:25ZengElsevierRespiratory Medicine Case Reports2213-00712020-01-0131101241Levetiracetam-induced interstitial lung disease in a patient with advanced lung cancerShintaro Sato0Tomohiro Oba1Hiroki Ohta2Yuta Tsukahara3Gen Kida4Emiri Tsumiyama5Kenji Kusano6Tomotaka Nishizawa7Rie Kawabe8Hideaki Yamakawa9Keiichi Akasaka10Masako Amano11Hidekazu Matsushima12Corresponding author. Department of Respiratory Medicine, Saitama Red Cross Hospital, 1-5 Shintoshin, Chuo-ku, Saitama, 330-8553, Japan.; Department of Respiratory Medicine, Saitama Red Cross Hospital, Saitama, JapanDepartment of Respiratory Medicine, Saitama Red Cross Hospital, Saitama, JapanDepartment of Respiratory Medicine, Saitama Red Cross Hospital, Saitama, JapanDepartment of Respiratory Medicine, Saitama Red Cross Hospital, Saitama, JapanDepartment of Respiratory Medicine, Saitama Red Cross Hospital, Saitama, JapanDepartment of Respiratory Medicine, Saitama Red Cross Hospital, Saitama, JapanDepartment of Respiratory Medicine, Saitama Red Cross Hospital, Saitama, JapanDepartment of Respiratory Medicine, Saitama Red Cross Hospital, Saitama, JapanDepartment of Respiratory Medicine, Saitama Red Cross Hospital, Saitama, JapanDepartment of Respiratory Medicine, Saitama Red Cross Hospital, Saitama, JapanDepartment of Respiratory Medicine, Saitama Red Cross Hospital, Saitama, JapanDepartment of Respiratory Medicine, Saitama Red Cross Hospital, Saitama, JapanDepartment of Respiratory Medicine, Saitama Red Cross Hospital, Saitama, JapanAn 85-year-old woman with antibiotics-resistant pneumonia after surgery for metastatic brain tumor from lung cancer was consulted to our department. Chest CT showed diffuse GGO bilaterally. BALF showed elevated ratios of lymphocytes and CD4/CD8. Tests for bacteria, mycobacteria, and fungi were negative. She improved following levetiracetam discontinuance and systemic corticosteroid administration, and we diagnosed levetiracetam-induced lung injury. Although levetiracetam is widely used, few reports of levetiracetam-induced pneumonia exist. Changes in chest images may occur after levetiracetam administration if patients have multiple risk factors for development of drug-induced interstitial lung disease. Bronchoscopy is useful for differential diagnosis if new lung lesions appear after starting levetiracetam.http://www.sciencedirect.com/science/article/pii/S221300712030455XDrug-induced interstitial lung diseaseLevetiracetamLung cancer |
| spellingShingle | Shintaro Sato Tomohiro Oba Hiroki Ohta Yuta Tsukahara Gen Kida Emiri Tsumiyama Kenji Kusano Tomotaka Nishizawa Rie Kawabe Hideaki Yamakawa Keiichi Akasaka Masako Amano Hidekazu Matsushima Levetiracetam-induced interstitial lung disease in a patient with advanced lung cancer Respiratory Medicine Case Reports Drug-induced interstitial lung disease Levetiracetam Lung cancer |
| title | Levetiracetam-induced interstitial lung disease in a patient with advanced lung cancer |
| title_full | Levetiracetam-induced interstitial lung disease in a patient with advanced lung cancer |
| title_fullStr | Levetiracetam-induced interstitial lung disease in a patient with advanced lung cancer |
| title_full_unstemmed | Levetiracetam-induced interstitial lung disease in a patient with advanced lung cancer |
| title_short | Levetiracetam-induced interstitial lung disease in a patient with advanced lung cancer |
| title_sort | levetiracetam induced interstitial lung disease in a patient with advanced lung cancer |
| topic | Drug-induced interstitial lung disease Levetiracetam Lung cancer |
| url | http://www.sciencedirect.com/science/article/pii/S221300712030455X |
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